Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Histomorphometric methods for age-at-death estimation constitute alternatives to macroscopic ones in the forensic context. However, all new methods must be tested on independent samples to justify their use and assure their accuracy. The main goal of this study was to test a new age-at-death method presented by Goliath et al. (2016) on a sample of 29 decalcified femur sections from individuals autopsied in the Institute of Legal Medicine of Montpellier, France. The formula proposed by the authors was not efficient to estimate the age-at-death in our sample, with only four out of 29 individuals well estimated. Despite this result, the same relationship between age and histomorphometric criteria was found, though at a lower intensity than what Goliath et al. previously found in their study. The use of a different bone preparation technique from Goliath et al. does not allow us to propose a definitive conclusion on the accuracy of this method.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.forsciint.2019.01.020 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Application of modified Poisson regression for risk estimation of major neuropathology outcomes: National Alzheimer's coordinating center.
J Alzheimers Dis
September 2025
Program for Research on Men's Health, Johns Hopkins Center for Health Disparities Solutions, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
Odds ratios (OR) can overestimate risk when the prevalence of outcomes is more than 10%. We compared logistic and modified Poisson models in 5843 National Alzheimer's Coordinating Center decedents to examine associations of apolipoprotein () ε4, age at death, sex, and education with 7 neuropathologies. OR for neuritic plaques (6.
View Article and Find Full Text PDFAmbient Air Pollution and the Severity of Alzheimer Disease Neuropathology.
JAMA Neurol
September 2025
Translational Neuropathology Research Laboratory, Department of Pathology and Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia.
Importance: Exposure to fine particulate matter air pollution (PM2.5) may increase risk for dementia. It is unknown whether this association is mediated by dementia-related neuropathologic change found at autopsy.
View Article and Find Full Text PDFMajor Causes of Perinatal and Paediatric Mortality in Sub-Saharan Africa and South Asia: Adjustment for Selection Bias in the CHAMPS Network.
Paediatr Perinat Epidemiol
September 2025
Rollins School of Public Health, Emory University, Atlanta, Georgia, USA.
Background: Studies of child mortality that employ minimally invasive tissue sampling (MITS) produce highly accurate cause of death data; however, selection bias may render these as non-representative of their underlying populations.
Objectives: Estimate cause-specific mortality fractions and rates for the five most frequent causes-underlying and others in the chain of events leading to death-among stillbirths, neonatal, infant and child deaths-in Sub-Saharan Africa and South Asia, adjusted for any identified selection biases.
Methods: The Child Health and Mortality Prevention Surveillance (CHAMPS) Network collects standardised, population-based, longitudinal data on causes of death among stillbirths and under-five children in 12 catchments in seven countries in Sub-Saharan Africa and South Asia.
Cortical Gray Matter Proteins Associated With Cerebral Amyloid Angiopathy in Community-Dwelling Older Adults: An Autopsy Study.
Neurology
September 2025
Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL.
Background And Objectives: Cerebral amyloid angiopathy (CAA) is the accumulation of β-amyloid (Aβ) in the walls of small vessels in the leptomeninges and cortex and is a risk factor of intracerebral hemorrhage and dementia, but its underlying mechanism is unknown. We examined cortical proteins in relation to CAA to elucidate the molecular mechanisms underlying CAA.
Methods: Data were collected from participants of 5 community-based cohorts of older adults.
Breaking the 50+ barrier: Cortical speed of sound via quantitative ultrasound as a new age-at-death estimator in older adults.
Forensic Sci Int
August 2025
Internal Medicine, Advocate Christ Medical Center, Oak Lawn, IL, United States.
The increasing number of forensic cases and solitary deaths ("kodokushi") involving older adults warrants targeted methods to serve this growing and vulnerable group. However, age-at-death estimation past midlife remains challenging due to diminished accuracy of traditional macroscopic age markers, often resulting in a single categorization of older age groups as "50 + ." This study evaluates the utility of cortical bone speed of sound (SoS), measured by quantitative ultrasound (QUS), as an alternative biomarker to quantify age-related changes in cortical bone quality and to estimate age-at-death in older adult skeletons.
View Article and Find Full Text PDF