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We report a case of Gorham-Stout disease (GSD) complicated by chylothorax and treated with a combination therapy with interferon and bisphosphonates. This treatment may be helpful in improving the usually unfavorable prognosis of GSD beginning with a chylothorax before 1 year of age, and in reducing bone lesions. Moreover, the use of bisphosphonates appears to be useful in treating pain.
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http://dx.doi.org/10.1159/000495364 | DOI Listing |
Front Endocrinol (Lausanne)
September 2025
Bone Physiopathology Research Unit, Translational Pediatric and Clinical Genetic Research Division, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.
The "vanishing bone disease" or Gorham-Stout disease (GSD) is a very rare disorder characterized by massive lymphatic and angiomatous proliferation accompanied by progressive osteolysis, without the deposition of new bone matrix. Because of its rare and complex clinical features, diagnosis is challenging and its etiopathogenesis is not completely known; the genetic basis of GSD has been hypothesized and different mutations have been reported in patients. Our review aims to describe all these genetic alterations found in GSD patients and their association with clinical features.
View Article and Find Full Text PDFMater Today Bio
October 2025
School and Hospital of Stomatology, Guangdong Engineering Research Center of Oral Restoration and Reconstruction, Guangzhou Key Laboratory of Basic and Applied Research of Oral Regenerative Medicine, Guangzhou Medical University, Guangzhou, 510182, China.
Rare earth nanomaterials, especially those incorporating neodymium, hold great potential for bone regeneration, but their clinical application is limited by insufficient understanding of immunomodulatory effects and potential toxicity concerns. To address this, we developed neodymium-doped mesoporous silica nanoparticles (NDMSN) to modulate macrophage autophagy and polarization. NDMSN exhibited uniform dispersion with an average size of 103 nm.
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August 2025
College of Pharmacy, Chungnam National University, Daejeon 34134, Korea.
Phloridzin, a natural compound derived from , exhibits a wide range of biological activities, making it a promising candidate for the development of functional foods aimed at promoting health and preventing disease. Gorham-Stout disease (GSD) is an orphan rare disorder defined by gradual bone resorption and vascular proliferation, with fewer than 400 cases documented, leading to severe pathological consequences. This study aims to examine the mechanisms underlying two key features of GSD, including progressive osteolysis, through osteoclastogenesis, and vascular proliferation, by examining endothelial and vascular cell proliferation.
View Article and Find Full Text PDFJBJS Essent Surg Tech
August 2025
Department of Orthopaedic Surgery, University of Pennsylvania, Philadelphia, Pennsylvania.
Background: Achieving adequate exposure can be difficult in cases of revision total hip arthroplasty (THA). Splitting the gluteus maximus muscle with use of a Kocher-Langenbeck approach is the most common technique when performing a posterior approach to the hip. However, superior exposure of the ilium is limited by the superior gluteal neurovascular bundle (SGB).
View Article and Find Full Text PDFCell Signal
November 2025
Institute of Anatomy and Cell Biology, University Medical Center Göttingen, Göttingen, Germany. Electronic address:
Ewing sarcoma (EwS) is characterized by a balanced chromosomal translocation in which a member of the FET gene family is fused with an E26 transformation specific (ETS) transcription factor: the most common fusion being EWSR1-FLI1. Traditionally, EwS includes Ewing-like tumors, Askin tumors, and peripheral primitive neuroectodermal tumors (PNET), indicative of a neuroectodermal relationship. Previously, in the absence of genetic diagnostics, extraosseous EwS could be mistaken for neuroblastoma (NB), which has become particularly clear in the history of the CHP100 cell line.
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