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Background/objectives: Epidemiological studies have shown an increased prevalence of attention deficit hyperactivity disorder (ADHD) in children with atopic dermatitis (AD), but many of the features of ADHD may occur as a result of the poor sleep and itch distraction associated with AD.
Methods: A case-control study was performed in children aged 6-17 years with moderate/severe AD compared with age-/sex-matched healthy controls. Participants were screened for ADHD using Vanderbilt assessments.
Results: Seventeen patients with AD and 18 controls completed the study. Two children with AD (11.7%) and one control (5.56%) met screening criteria for ADHD via parent-completed Vanderbilt assessments; AD patients were not significantly more likely to screen positive for ADHD (P = 0.47), or comorbid behavior disorders (P = 0.23). However, AD patients were more likely than controls to exhibit ADHD-associated behaviors, most significantly inattention.
Conclusions: Our AD cohort did not have a significantly increased prevalence of ADHD. Certain neurocognitive symptoms are increased in children with moderate-to-severe AD compared to controls.
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http://dx.doi.org/10.1111/pde.13710 | DOI Listing |
J Allergy Clin Immunol Pract
September 2025
COPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Background: Studies have described sex differences in childhood asthma, allergy, and atopic dermatitis, but the development and clinical phenotype of these differences remain poorly understood.
Objective: To characterize sex differences in atopic disease throughout childhood and study the potential role of sex-steroid metabolites.
Methods: We examined sex differences in asthma, allergy, and atopic dermatitis using longitudinal generalized estimating equation models in the COPSAC (n=411) and COPSAC (n=700) birth cohorts.
J Allergy Clin Immunol
September 2025
State Key Laboratory of Chemical Biology, Shanghai Institute of Materia Medica, Shanghai, China; University of Chinese Academy of Sciences, Beijing, China. Electronic address:
Background: Keratinocytes form the skin's first line of defense, not only serving as a physical barrier but also actively communicating with immune cells and sensory neurons.
Objective: To elucidate the molecular mechanisms by which keratinocytes contribute to barrier dysfunction and neuroimmune activation in atopic dermatitis (AD).
Methods: CB2R expression was assessed by RNA-seq, qRT-PCR, RNAscope fluorescence, and western blot.
Dermatitis
September 2025
From the Division of Dermatology, Rabin Medical Center - Beilinson Hospital, Petach Tikva, Israel.
There are limited data regarding photopatch testing (PPT) in Israel. To investigate the prevalence of positive reactions and concurrent diagnosis of patients that underwent PPT in a single center in Israel. Retrospective cohort study that included all patients that were suspected of having contact dermatitis and underwent patch testing with the European baseline series (EBS) and additionally were selectively PPT with the Scandinavian/European baseline photopatch series in a tertiary medical center in Israel (2009-2023).
View Article and Find Full Text PDFDermatitis
September 2025
From the Biosanitary Research Institute of Granada (ibs.GRANADA), Granada, Spain.
Atopic dermatitis (AD) is a common chronic inflammatory skin condition influenced by genetic and environmental factors. The role of lifestyle on AD remains unclear. This study explores the association between adherence to the Mediterranean diet (MD), physical activity (PA) levels, and AD severity.
View Article and Find Full Text PDFJ Invest Dermatol
September 2025
Department of Dermatology, School of Medicine, University of California San Diego, San Diego, California, USA. Electronic address: