Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Atopic dermatitis (AD) is a chronic inflammatory skin disease that is not fully understood. Defects in skin barrier function and dysregulation of the Th2 immune response are thought to be pivotal in AD pathogenesis. In this study, we used keratinocytes and AD-like skin equivalent models using Th2 cytokines IL-4 and IL-13. The keratinocytes and AD-like skin model were used to investigate the effect of dipotassium glycyrrhizinate (KG), which is widely used as an anti-inflammatory agent for AD treatment. KG decreased AD-related gene expression in keratinocytes stimulated with Th2 cytokines. KG alleviated AD-like phenotypes and gene expression patterns and inhibited release of AD-related cytokines in the AD-like skin equivalent models. These findings indicate KG has potential effectiveness in AD treatment and AD-like skin equivalent models may be useful for understanding AD pathogenesis.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1007/s00403-018-1883-z | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
N-acetyl-L-alanine ameliorates atopic dermatitis-like symptoms by suppressing Th2 differentiation in DNFB-induced NC/Nga mice.
BMB Rep
September 2025
Department of Microbiology, Jeonbuk National University Medical School, Jeonju 54896; Department of R&D, Cutiimunebio Inc., Jeonju 54907, Korea.
Atopic dermatitis (AD) is a chronic dermatological disorder characterized by intense pruritus and eczematous lesions. Repeated topical application of 2,4-dinitrofluorobenzene (DNFB) in NC/Nga mice produces AD-like clinical symptoms that closely resemble human AD. N-Acetyl-L-Alanine (L-NAA), a derivative of L-Alanine, has unknown biological and physiological effects on cutaneous tissue.
View Article and Find Full Text PDFElevated Kocuria rhizophila contributing to repair of skin barrier function in patients with atopic dermatitis.
Allergol Int
August 2025
Department of Pediatrics, Soonchunhyang University Gumi Hospital, Gumi, South Korea; Department of Pediatrics, National Jewish Health, Denver, CO, USA. Electronic address:
Background: Recent findings suggest skin microbiota is closely linked to the aggravation of atopic dermatitis (AD) and skin barrier dysfunction.
Methods: This prospective cross-sectional study included 52 children: 35 with AD flare (F) and non-flare (NF), and 17 without AD (non-AD). Microbes in the skin samples from the three groups were analyzed using 16S rRNA amplicon sequencing.
Protocatechuic aldehyde inactivates STAT3 through disrupting the STAT3-JAK1 interaction in epidermal keratinocyte and improves atopic dermatitis-like skin inflammation.
Int Immunopharmacol
August 2025
Engineering Research Center of Sichuan-Tibet Traditional Medicinal Plant, Chengdu University, Chengdu 610106, China; Natural Products Chem-bio Innovation Center, Chengdu 8 University, Chengdu 610106, China; School of Basic Medical Sciences, Chengdu University, Chengdu 610106, China. Electronic addre
Protocatechuic aldehyde (PA) is an active compound of Salvia miltiorrhiza (Danshen), a traditional Chinese herb wildly used for inflammatory skin diseases therapy. STAT3 activation plays a pivotal role in multiple inflammatory cutaneous diseases. We previously reported that topical treatment with PA ameliorated psoriasis-like skin inflammation, a typical Th1-mediated inflammatory skin disease, by inactivating STAT3.
View Article and Find Full Text PDFThe Role of Dupilumab in Atopic Dermatitis-Like Graft-Versus-Host Disease.
Cureus
July 2025
Pediatric Allergology Unit, Centro Materno Infantil do Norte, Unidade Local de Saúde de Santo António, Porto, PRT.
Atopic dermatitis-like graft-versus-host disease (AD-like GVHD) is a rare but challenging complication following hematopoietic stem cell transplantation (HSCT), mimicking features of atopic dermatitis (AD) and often requiring prolonged immunosuppression. We report the case of a 14-year-old girl with a history of mild AD and post-HSCT GVHD involving skin and the gastrointestinal tract, presenting with severe pruritus, extensive eczema, and significant impact on quality of life. Standard treatment with corticosteroids and immunosuppressants yielded suboptimal results and notable side effects, including growth retardation.
View Article and Find Full Text PDFProtective Effect of Extract on 2,4-Dinitrochlorobenzene (DNCB)-Induced Atopic Dermatitis in an SKH-1 Mouse Model.
Int J Mol Sci
July 2025
Department of Convergence Medicine, Wonju College of Medicine, Yonsei University, Wonju 26426, Republic of Korea.
Atopic dermatitis (AD) is a common chronic inflammatory skin disorder characterized by immune dysregulation and skin barrier impairment. This study evaluated the anti-inflammatory and immunomodulatory effects of extract in a 2,4-dinitrochlorobenzene (DNCB)-induced AD mouse model using SKH-1 hairless mice. Topical application of extract for four weeks significantly alleviated AD-like symptoms by reducing epidermal thickness, mast cell infiltration, and overall skin inflammation.
View Article and Find Full Text PDF