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Purpose: Chronic wounds are a major public health challenge, but little is known about the true burden with studies reporting different estimates because of disparities in study designs and measurement methods. This hampers efficient resource allocation, planning, and improvement of wound care.
Methods: Our study aimed to pool prevalence estimates from a global perspective by systematically carrying out searches in MEDLINE, EMBASE, Cochrane, CINAHL, Global Health, and PsycINFO databases for articles reporting the prevalence of chronic wounds in adults, from January 2000 to June 2018. The included publications had to define wound chronicity by duration (≥3 weeks), and/or labeling the wounds as chronic, complex, or hard-to-heal.
Results: Seventeen studies met the inclusion criteria, and 11 studies analyzing chronic wounds in the general population were included in random effects meta-analyses to calculate pooled prevalence. Chronic wounds of mixed etiologies (n = 3) showed a pooled prevalence of 2.21 per 1000 population, and for chronic leg ulcers (n = 9), the prevalence was estimated at 1.51 per 1000 population.
Conclusions: Our findings, aligned to previous studies reporting point prevalence of chronic wounds identified within the healthcare system, showed that the vast majority of chronic wounds in epidemiological studies are made up by chronic leg ulcers.
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http://dx.doi.org/10.1016/j.annepidem.2018.10.005 | DOI Listing |
Spinal Cord Ser Cases
September 2025
Rehabilitation Sciences Institute, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada.
Study Design: Concurrent mixed methods case series.
Objectives: To examine the feasibility and effect of a peer-facilitated, remote handcycling sport program on physical, psychological, and social health of individuals with spinal cord injury or disease (SCI/D) aged ≥50 years.
Setting: Participants' homes.
Biomed Mater
September 2025
Department of Nanobiotechnology, Faculty of Biological Sciences, , Tarbiat Modares University, Tehran, P.O. Box 14115-154, Iran, Tehran, Tehran Province, 14115-154, Iran (the Islamic Republic of).
It is essential to develop new strategies for wound treatment and skin reconstruction, particularly by scaffolds that replicate the structure and function of native skin. A bilayer scaffold was developed using three-dimensional (3D) bioprinting, based on a uniform chitosan-based formulation for both layers, maintaining material uniformity while offering structural support and promoting cell adhesion. The upper chitosan layer, embedded with NHEK-Neo, is stiffer and mimics the epidermis, while the softer lower layer contains embedded HFFs and HFSCs, mimicking the dermis.
View Article and Find Full Text PDFMetab Brain Dis
September 2025
Hubei Key Laboratory of Tumor Microenvironment and Immunotherapy, China Three Gorges University, Yichang, 443002, Hubei, China.
Demyelinating diseases, a prevalent group of neurological disorders, lead to impaired nerve conduction and sensorimotor dysfunctions. Despite existing treatments demonstrating some efficacy, their limitations have driven research toward exploring natural remedies. This review summarizes the therapeutic potential of four traditional tonic Chinese herbal medicines-ginsenosides, deer antler polypeptides, resveratrol, and ginkgo leaf extracts-for demyelinating diseases.
View Article and Find Full Text PDFAmino Acids
September 2025
Colorectal Research Center, Iran University of Medical Sciences, Tehran, 1445613131, Iran.
Anal fissure causes pain and bleeding during or after bowel movements, significantly impacting individuals' quality of life. Current treatments aim to interrupt this cycle but have associated risks and limitations. The emergence of arginine, crucial for protein creation and nitric oxide (NO) production, presents an intriguing therapeutic avenue by the impact on reducing anal sphincter pressure and enhancing anoderm blood flow, due to its roles in vasodilation, anti-inflammatory responses, and collagen synthesis, which can promote wound healing and highlighting its potential as an alternative therapy.
View Article and Find Full Text PDFKhirurgiia (Mosk)
September 2025
Mogilev Regional Clinical Hospital, Mogilev, Republic of Belarus.
Objective: To evaluate clinical and laboratory effectiveness of ultrasound treatment for purulent wounds.
Material And Methods: The study enrolled 46 patients with purulent wounds divided into the main group (23 patients, ultrasonic treatment) and the control group (23 patients, traditional treatment). We assessed treatment effectiveness considering visual data, quality of granulation tissue, wound defect area and marginal epithelialization, complete blood count and C-reactive protein.