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The emergence of mobile colistin resistance genes (mcr) is yet another challenge in the fight against antimicrobial resistance, with reports proving the dissemination of these genes in different countries and different environments being of great concern. In the present study, we describe the recovery of three E. coli strains with mcr-1 gene in IncHI2 plasmids from intestinal content of necropsied meat rabbits reared in two intensive production systems in Portugal. Our findings are worrisome, given the high level of dependence on the usage of antibiotics in rabbit rearing and call for the development and implementation of an active surveillance system in this species.
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http://dx.doi.org/10.1016/j.vetmic.2018.10.020 | DOI Listing |
J Glob Antimicrob Resist
September 2025
Key Laboratory of Jilin Province for Zoonosis Prevention and Control, Changchun Veterinary Research Institute, Chinese Academy of Agriculture Sciences, Changchun, Jilin 130122, China. Electronic address:
Objectives: The usage of cephalosporins (CEFs) and co-existence of extended-spectrum β-lactamase (ESBL) gene bla in the same host may promote the prevalence of colistin (CST) resistance gene mcr-1. This study aims to investigate the underlying mechanisms how the mcr-1 and bla demonstrate significant co-occurrence in Escherichia coli (E. coli).
View Article and Find Full Text PDFPathogens
July 2025
Department of Genetics, Development and Molecular Biology, School of Biology, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece.
has emerged as a major pathogen responsible for healthcare-associated infections, particularly in intensive care units, contributing to significant morbidity and mortality due to its multidrug resistance and ability to persist in clinical environments. This study aimed to investigate the phenotypic and genomic characteristics of all multidrug-resistant isolates collected between January and June 2022 from two tertiary care hospitals in Thessaloniki, Greece. A total of 40 isolates were included.
View Article and Find Full Text PDFAnn Med
December 2025
Division of Virology, Department of Pathology, University of Cambridge, England, UK.
Introduction/background: Antimicrobial resistance (AMR) remains a critical global health issue, particularly in low- and middle-income countries like Nigeria. Colistin, a last-resort antibiotic for multidrug-resistant Gram-negative infections, has seen rising resistance, posing a significant challenge for neonatal sepsis management. This narrative review focuses on colistin resistance in neonates in Nigeria, addressing a critical public health threat.
View Article and Find Full Text PDFAfr Health Sci
June 2025
Hacettepe University, Faculty of Medicine, Department of Medical Microbiology, Ankara, Turkey.
Background: Increase in antimicrobial resistance poses a global threat for treatment of Salmonellosis.
Objectives: In this study, serovar distribution, antimicrobial susceptibility, resistance genes, and clonal diversity were characterized in clinical isolates.
Methods: In this study, serovar distribution of clinical isolates was characterized by the Kauffman-White scheme.
Mol Biol Rep
August 2025
Unit for Environmental Sciences and Management, North-West University, Potchefstroom, 2531, South Africa.
Background: The gut microbiota of Testudines is fundamental to their digestion and overall health, yet remains a poorly investigated area in their biology, particularly in wild freshwater turtle (terrapins) and tortoise populations within South Africa. This study investigated the occurrence, diversity, virulence genes and antibiotic resistance of Escherichia coli isolated from Testudine gut microbiota and sediments at Timbavati Private Nature Reserve, South Africa.
Methods And Results: Cloacal swab samples were collected from 36 wild Testudines and 20 sediment samples from temporary and permanent water bodies.