98%
921
2 minutes
20
Download full-text PDF |
Source |
---|---|
http://dx.doi.org/10.1016/j.jacc.2018.08.2190 | DOI Listing |
Chem Biodivers
September 2025
Department of Clinical Pharmacy, College of Pharmacy, University of Sulaimani, Sulaimani, Iraq.
The global rise in antibiotic resistance demands the urgent development of new antibacterial agents. This study investigated the antibacterial potential of four synthesized methoxy and thiophene chalcone derivatives (designated 3a, 4a, 3b, and 4b) against clinically relevant bacterial pathogens. These compounds were prepared through Claisen-Schmidt condensation, while their chemical structures were verified through applying Fourier-transform infrared, mass spectrometry, H nuclear magnetic resonance (NMR), and C NMR.
View Article and Find Full Text PDFChem Biodivers
September 2025
Key Lab of Natural Product Chemistry and Application at Universities of Education, Department of Xinjiang Uygur Autonomous Region, School of Chemistry and Chemical Engineering, Yili Normal University, Xinjiang, China.
The persistent threat posed by phytopathogenic fungi to agricultural systems underscores the critical need for novel fungicides. Here, we synthesized and characterized a series of novel acridospiroisoxazole derivatives (H1-H36) using H/C NMR and mass spectrometry. The absolute configuration of compound H23 was confirmed using single-crystal x-ray diffraction analysis.
View Article and Find Full Text PDFMol Pharm
September 2025
Center for Orthopedic Surgery, The Third Affiliated Hospital of Southern Medical University, Guangzhou 510630, China.
Myocardial fibrosis, a key pathological feature of hypertensive heart disease (HHD), remains diagnostically challenging due to limited clinical tools. In this study, a FAPI-targeted uptake mechanism previously reported by our group, originally developed for tumor imaging, is extended to the detection of myocardial fibrosis in HHD using [F]F-NOTA-FAPI-MB. The diagnostic performance of this tracer is compared with those of [F]F-FDG, [F]F-FAPI-42, and [F]F-NOTA-FAP2286, and its potential for fluorescence imaging is also evaluated.
View Article and Find Full Text PDFPhysiol Rep
September 2025
University of Jendouba, Laboratory of Functional Physiology and Valorization of Bio-Resources, Higher Institute of Biotechnology of Béja, Béja, Tunisia.
Constipation is a common gastrointestinal disorder characterized by infrequent and difficult bowel movements, hard stool consistency, and delayed intestinal transit. The present study evaluated the phytochemical profile and physiological effects of the aqueous extract of beetroot leaves (AEBL) in a rat model of Loperamide (LOP)-induced constipation. Thirty-six male Wistar rats were randomly assigned to six groups (n = 6): two controls (normal and constipated) and four constipated groups receiving either increasing doses of AEBL (100, 200, or 400 mg/kg, b.
View Article and Find Full Text PDFFood Res Int
November 2025
Tea Research Institution, Yunnan Academy of Agricultural Sciences, Kunming 650200, China; Yunnan Key Laboratory of Tea Science, Tea Research Institution, Yunnan Academy of Agricultural Sciences, Kunming 650200, China. Electronic address:
Pu-erh raw tea (PRT), a post-fermented tea, is prized for its complex flavor profile and health-promoting properties. While extended storage enhances its sensory attributes, the decade-scale metabolic dynamics underpinning flavor evolution remain unexplored. This study comprehensively characterized non-volatile metabolomic profiles and flavor changes in PRT across a 10-year storage period (2012-2023).
View Article and Find Full Text PDF