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Background: First carpometacarpal (CMC) joint osteoarthritis (OA) is commonly encountered in clinical practice. The preferred surgical option when conservative therapy fails varies with the stage and nature of the disease. Denervation of the first CMC joint is a relatively new procedure for managing stable thumb CMC joint OA. Our objective was to review our experience and surgical technique with first CMC joint denervation surgery.
Methods: All patients who underwent first CMC joint denervation surgery from January 2015 through September 2017 were retrospectively identified. Before undergoing surgical CMC denervation, patients received a joint block at the first CMC joint with 0.25% bupivacaine. Only patients with a good response to injection were selected for surgical denervation. Patient demographics, preoperative and postoperative pain scores using a numeric rating scale, and grip strength using the Jamar Hydraulic Hand Dynamometer were analyzed.
Results: Of 10 patients (13 hands) with CMC joint OA, 8 patients (11 hands) met the inclusion criteria. Patients' average grip strength improved significantly after the procedure (from 38.4 ± 26.7 foot/lb to 50.2 ± 27.6 foot/lb; P = 0.007). The numeric rating scale pain score improved significantly from 7.8 ± 2.4 to 2.4 ± 1.8 (P < 0.001). Seven of 8 patients reported satisfaction with surgery. There were 2 complications.
Conclusions: First CMC joint denervation provided good pain relief and improvement in grip strength in patients with thumb CMC joint OA. This minimally invasive technique proved to be a good option for providing optimal pain control and improvement in strength with minimal and mild complications.
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http://dx.doi.org/10.1016/j.wneu.2018.11.061 | DOI Listing |
Int J Biol Macromol
September 2025
College of Pharmacy, Guangxi University of Chinese Medicine, Nanning 530200, China. Electronic address:
Conductive hydrogels have emerged as promising materials for flexible wearable electronics; however, their facile fabrication remains challenging. This study presents an antifreeze, antibacterial, and conductive hydrogel constructed from biomacromolecules sodium carboxymethylcellulose (CMCNa) and polyvinyl alcohol (PVA). The hydrogel was synthesized via a simple one-pot method in an ethylene glycol/water (EG/H₂O) binary solvent system, incorporating lithium chloride (LiCl) and clove essential oil (CEO), followed by a single freeze-thaw cycle.
View Article and Find Full Text PDFJ Hazard Mater
September 2025
Sinopec Research Institute of Petroleum Processing Co., LTD, Beijing 100083, China; Key Laboratory of Soil and Groundwater Pollution Control and Green Restoration, Sinopec, China.
Surfactant-enhanced aquifer remediation (SEAR) is an effective strategy for removing dense non-aqueous phase liquids (DNAPLs) from contaminated groundwater. While Gemini surfactants possess unique dimeric structures and excellent physicochemical properties, the role of hydrophobic chain length in governing their solubilization performance has not been systematically clarified. Here, five sugar-based anionic-nonionic Gemini surfactants (SANG 06, 08, 09, 10, and 13) with different hydrophobic chain lengths were synthesized and evaluated.
View Article and Find Full Text PDFCureus
July 2025
Orthopedic Surgery, University of Arizona College of Medicine, Phoenix, USA.
Background: Joint denervation procedures continue to demonstrate promise in the management of chronic pain and functional improvement in joint pathology of the hand and wrist. As our understanding of these techniques evolves, a detailed comprehension of neuroanatomy, including the precise relationships and contributions of sensory innervation to targeted joints, is critical for optimizing outcomes.
Methods: Freshly thawed frozen upper extremity cadaveric specimens were analyzed under the direction of two fellowship-trained hand surgeons.
J Hand Surg Glob Online
November 2025
Hospital Nova of Central Finland, Wellbeing Services County of Central Finland, Jyväskylä, Finland.
Purpose: This study aimed to assess how much symptoms resolve during a 6-week continued nonsurgical treatment with an orthosis and after trapeziectomy in people with thumb carpometacarpal joint osteoarthritis (CMC-1 OA) referred for surgical consultation. The data on symptom resolution magnitude and trajectory can help inform patients about postsurgical recovery and assist researchers in designing clinical trials to evaluate surgery's effectiveness for CMC-1 OA.
Methods: We recruited 52 patients with CMC-1 OA referred for surgical consultation.
Hand Ther
August 2025
Department of Biostatistics, Social Determinants of Health Research Center, University of Social Welfare and Rehabilitation Sciences, Tehran, Iran.
Introduction: To our knowledge, no previous studies have directly compared the effects of orthosis wear in males and females with thumb carpometacarpal (CMC) joint osteoarthritis. Therefore, this study aimed to analyze whether there are differences between males and females in pain, hand function, and grip strength following hand-based orthosis wear.
Methods: The study included 14 male and 14 female participants with first- and second-degree CMC joint osteoarthritis.