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Article Abstract
Rotifers have been widely used as well-characterized models of aging, since their multiorgan character makes them suitable as toxicological and lifespan models. Here we report the assessment of four adaptogenic plants and their extracts for the first time in this model. The effects on rotifer viability of extracts and characteristic active markers of , , and were tested . The crude extracts were nontoxic to bdelloid rotifers; however, the pure substances of the plants influenced negatively the viability. Ginsenoside Rb1 and secondary metabolites of exerted deleterious effect on the animals. The aglycone tyrosol and cinnamyl alcohol (from ) were more toxic than their glycosides salidroside and rosavin. Although the 20-OH-ecdysone and ajugasterone C (from ) are chemically very similar, the latter was less toxic.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6204184 | PMC |
| http://dx.doi.org/10.1155/2018/3690683 | DOI Listing |
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