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With the continuous pursuit of high brightness and low power consumption display technology, RGBW display technology has been attracting increasing attention in the world. Various kinds of displays based on this technology have been produced in the market. The key of this technology is signal mapping algorithm which converts RGB signal into RGBW signal without color distortion and compatible with different sub-pixel layouts. This paper, on the basis of five kinds of signal mapping algorithms, analyzes the mode of action of newly added white sub-pixel affects display color, and the display performance affected by four kinds of sub-pixel layouts; it proposes the corresponding condition of excellent signal mapping algorithm based on colorimetry and deduces the universal equation of excellent signal mapping algorithm and brightness factor which could measure the ability of enhancing brightness. The simulation experiment shows that the signal mapping algorithm which satisfies universal equation could be able to maintain the hue and saturation better. The signal mapping algorithm’s ability to enhance brightness is effectively characterized by brightness factor. In conclusion, the proposed universal equation can be used to evaluate existing signal mapping algorithms, and it provides theoretical references for the research of new signal mapping algorithm which could be compatible with different hardware parameters and sub-pixel layouts, promote the popularization of RGBW display technology.
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Cereb Cortex
August 2025
Section on Functional Imaging Methods & Functional MRI Core Facility, National Institute of Mental Health, 10 Center Drive, Rm 1D80, Bethesda, MD 20892, United States.
Statistical Parametric Mapping (SPM) has been profoundly influential to neuroimaging as it has fostered rigorous, statistically grounded structure for model-based inferences that have led to mechanistic insights about the human brain over the past 30 years. The statistical constructs shared with the world through SPM have been instrumental for deriving meaning from neuroimaging data; however, they require simplifying assumptions which can provide results that, while statistically sound, may not accurately reflect the mechanisms of brain function. A platform that fosters the exploration of the rich and varying neuronal and physiologic underpinnings of the measured signals and their associations to behavior and physiologic measures needs a different set of tools.
View Article and Find Full Text PDFBiochem J
September 2025
Department of Biological Sciences, Indian Institute of Science Education and Research Kolkata, Mohanpur Campus, Mohanpur, 741246 Nadia, West Bengal, India.
Transcription initiation factor TFIID subunit 1 (TAF1) is a pivotal component of the TFIID complex, critical for RNA polymerase II-mediated transcription initiation. However, the molecular basis by which TAF1 recognizes and associates with chromatin remains incompletely understood. Here, we report that the tandem bromodomain module of TAF1 engages nucleosomal DNA through a distinct positively charged surface patch on the first bromodomain (BD1).
View Article and Find Full Text PDFMetab Brain Dis
September 2025
Department of Pharmacy, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, No. 1277, Jiefang Avenue, Wuhan, Hubei, 430022, China.
Major depression disorder (MDD) is a mental condition that significantly threatens both physical and psychological health. This study aimed to discern variances in plasma metabolic profiles between MDD sufferers and healthy counterparts. Additionally, we tracked the hospitalization journey of MDD patients to investigate the normalization of metabolic irregularities through conventional treatment in the form of self-control.
View Article and Find Full Text PDFFront Immunol
September 2025
Department of Thoracic Surgery, Shenzhen People's Hospital (The First Affiliated Hospital, Southern University of Science and Technology; The Second Clinical Medical College, Jinan University), Shenzhen, Guangdong, China.
Background: Lung cancer remains the leading cause of cancer-related mortality globally, primarily due to late-stage diagnosis, molecular heterogeneity, and therapy resistance. Key biomarkers such as EGFR, ALK, KRAS, and PD-1 have revolutionized precision oncology; however, comprehensive structural and clinical validation of these targets is crucial to enhance therapeutic efficacy.
Methods: Protein sequences for EGFR, ALK, KRAS, and PD-1 were retrieved from UniProt and modeled using SWISS-MODEL to generate high-confidence 3D structures.
FASEB Bioadv
September 2025
Kobilka Institute of Innovative Drug Discovery, School of Medicine The Chinese University of Hong Kong Shenzhen Guangdong China.
Formyl peptide receptor 1 (FPR1) is a G protein-coupled receptor (GPCR) that mediates chemotaxis and bactericidal activities in phagocytes. The monoclonal antibody 5F1 is generated against full-length FPR1 and used widely for detection of FPR1 expression. This study aimed to characterize 5F1 for its functions.
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