Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Objective: To investigate the role of the serum inhibin B (INHB) level in evaluating the testicular function of the prepubertal patient with varicocele (VC) after high ligation of the spermatic vein (HLSV).
Methods: This study included 31 prepubertal male patients with left VC, averaging 12.55 years of age and 9 complicated by right VC. We collected peripheral blood samples before and at 4, 12 and 26 weeks after HLSV as well as spermatic venous blood samples intraoperatively for determination of the levels of follicle-stimulating hormone (FSH), luteinizing hormone (LH), testosterone (T), anti-sperm antibody (AsAb) and serum INHB by ELISA.
Results: Compared with the baseline, statistically significant differences were observed in the INHB level in the peripheral blood at 12 and 26 weeks after operation (［255.18 ± 69.97］ vs ［141.78 ± 59.82］ pg/ml, P < 0.05) and that in the spermatic venous blood intraoperatively (［255.18 ± 69.97］ vs ［412.44 ± 259.42］ pg/ml, P < 0.01). Spearman's analysis showed a negative correlation between the level of INHB and that of FSH (r = －0.224, P < 0.01).
Conclusions: The level of serum INHB in the peripheral blood of the prepubertal VC patient is decreased within 6 months after HLSV and negatively correlated with that of FSH. The levels of INHB and FSH may well reflect the testicular function of the prepubertal VC patient.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Blocking T-type calcium channels disrupts spermatogenesis in vivo and adversely affects spermatocytes in vitro by impairing mitochondrial function and autophagic flux.
Reprod Toxicol
September 2025
Institute of Reproductive Medicine, Medical School, Nantong University, Nantong, Jiangsu 226019, China. Electronic address:
T-type calcium channels are pivotal in spermatogenesis. To evaluate the molecular mechanisms by which T-type calcium channels regulate spermatogenesis, we constructed animal and cellular models using T-type calcium channel inhibitor flunarizine (FNZ). Intraperitoneal administration of FNZ (30mg/kg) significantly impaired sperm motility, inhibited testicular germ cell proliferation, and disrupted sperm mitochondrial function in male mice.
View Article and Find Full Text PDFProbiotic effects of Saccharomyces cerevisiae on immune response, testicular function, serum pituitary-gonadal hormones and stress markers following localized scrotal heat exposure.
J Therm Biol
September 2025
Department of Animal and Diary Sciences, University of Wisconsin, Madison, USA.
Owing to the anti-inflammatory and anti-oxidant benefits of Saccharomyces cerevisiae (SC), 20 mature male albino rats, assigned into four groups (A-D; n = 5), were used to investigate its ameliorative effects on heat stress-induced testicular and humoral alterations. Group A rats were neither treated with SC nor exposed to heat [-SC, -HS]. Group B rats were treated with 7 mg/kg of SC, but were not exposed to heat [+SC, -HS].
View Article and Find Full Text PDFSodium orthovanadate alleviates lethal effect of total-body irradiation in mice without impairing recovery of male reproductive function.
Radiat Environ Biophys
September 2025
Graduate School of Biomedical Sciences, Tokushima University, Tokushima, Japan.
Sodium orthovanadate (vanadate), a potent inhibitor of p53, has been shown in earlier work to alleviate total-body irradiation (TBI)-induced hematopoietic syndrome. However, as p53 plays a crucial role in normal spermatogenesis, its suppression may raise concerns about potential adverse effects on male reproductive function. In this study, we investigated whether vanadate exacerbates impairment of male fertility when administered for hematopoietic protection under TBI conditions.
View Article and Find Full Text PDFDiabetic testicular dysfunction and spermatogenesis impairment: mechanisms and therapeutic prospects.
Front Endocrinol (Lausanne)
September 2025
Andrology Department of Integrative Medicine, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, Jiangsu, China.
With the global prevalence of diabetes mellitus (DM) steadily increasing, its impact on male reproductive health has become a growing area of concern. Diabetes-induced testicular damage involves alterations in testicular cell function, hormone levels, and the integrity of the blood-testis barrier (BTB), ultimately disrupting spermatogenesis. The key pathogenic factors include hyperglycemia, oxidative stress, chronic inflammation, mitochondrial dysfunction, and the accumulation of advanced glycation end products (AGEs).
View Article and Find Full Text PDFAmeliorative effects of var. ethanol extract and fractions on cimetidine-induced reproductive toxicity in male Wistar rats.
Front Vet Sci
August 2025
Department of Biochemistry, Faculty of Biomedical Sciences, Kampala International University Western Campus, Bushenyi, Uganda.
Background: Male infertility is a global health issue, with pharmaceutical agents such as cimetidine contributing significantly to gonadotoxicity through antiandrogenic and oxidative mechanisms. The search for natural protective agents has highlighted var. (collard greens) for its antioxidant and endocrine-modulating properties.
View Article and Find Full Text PDF