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Article Abstract
The octahedral rhenium cluster compound NaH[{ReSe}(P(CHCONH)(CHCOO))] has recently emerged as a very promising X-ray contrast agent for biomedical applications. However, the synthesis of this compound is rather challenging due to the difficulty in controlling the hydrolysis of the initial P(CHCN) ligand during the reaction process. Therefore, in this report we compare the and toxicity of NaH[{ReSe}(P(CHCONH)(CHCOO))] with those of related compounds featuring the fully hydrolysed form of the phosphine ligand, namely NaH[{ReQ}(P(CHCOO))] (Q = S or Se). Our results demonstrate that the cytotoxicity and acute toxicity of the complex NaH[{ReSe}(P(CHCONH)(CHCOO))] solutions were considerably lower than those of compounds with the fully hydrolysed ligand P(CHCOOH). Such behavior can be explained by the higher osmolality of NaH[{ReQ}(P(CHCOO))] NaH[{ReSe}(P(CHCONH)(CHCOO))].
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6060950 | PMC |
| http://dx.doi.org/10.1039/c7tx00083a | DOI Listing |
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