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Article Abstract
Background: Mismatch negativity (MMN) is a typical event-related potential component reflecting pre-attentive processing. MMN impairment, especially reduced duration-related MMN (dMMN), has been suggested as a potential predictive biomarker for the onset of schizophrenia.
Objective: This study attempts to manipulate specific MMN activities using advanced neuroimaging-guided intermittent theta-burst stimulations (iTBS), which will be helpful to uncover the sources of MMN generation and contribute to the development of new clinical treatments.
Methods: Twenty-four healthy volunteers were recruited and participated two-session modulations consisting of active and sham iTBS. ITBS was precisely delivered over individual right posterior superior temporal cortex (pSTG). Before and after each iTBS session, two MMN components evoked by duration and frequency deviants were quantified respectively.
Results: A significant interaction of time and iTBS was observed on dMMN amplitudes, but not frequency-related MMN amplitudes. dMMN only decreased after active precise iTBS intervention, but did not after sham iTBS. The post effect of iTBS on dMMN was found in 16 of 20 subjects, suggesting a robust effect even at individual level. Furthermore, sLORETA analysis showed that the lateralization of STG activation was reversed after the active iTBS.
Conclusions: We applied a precise strategy for neuroimaging-guided iTBS modulation over the right pSTG, which is promising in selectively modulating MMN for specific deviants.
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| http://dx.doi.org/10.1016/j.biopsycho.2018.08.001 | DOI Listing |
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