Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Garcinia L. (Clusiaceae) fruits are a rich source of (-)-hydroxycitric acid, and this has gained considerable attention as an anti-obesity agent and a popular weight loss food supplement. In this study, we assessed adulteration of morphologically similar samples of Garcinia using DNA barcoding, and used NMR to quantify the content of (-)-hydroxycitric acid and (-)-hydroxycitric acid lactone in raw herbal drugs and Garcinia food supplements. DNA barcoding revealed that mostly G. gummi-gutta (previously known as G. cambogia) and G. indica were traded in Indian herbal markets, and there was no adulteration. The content of (-)-hydroxycitric acid and (-)-hydroxycitric acid lactone in the two species varied from 1.7% to 16.3%, and 3.5% to 20.7% respectively. Analysis of ten Garcinia food supplements revealed a large variation in the content of (-)-hydroxycitric acid, from 29 mg (4.6%) to 289 mg (50.6%) content per capsule or tablet. Only one product contained quantifiable amounts of (-)-hydroxycitric acid lactone. Furthermore the study demonstrates that DNA barcoding and NMR could be effectively used as a regulatory tool to authenticate Garcinia fruit rinds and food supplements.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6043575 | PMC |
| http://dx.doi.org/10.1038/s41598-018-28635-z | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Combination of hydroxycitric acid and capsaicin regulates IRS-1/AMPK-mTOR-SREBP-1c Axis/NLRP3-NF-κB/Nrf-2-ARE signaling pathways to ameliorate the two-hit process in high-fat diet-induced hepatic steatosis.
Biochim Biophys Acta Mol Cell Biol Lipids
August 2025
Chandigarh University, Gharuan, Mohali 140413, Punjab, India.
Metabolic (Dysfunction) Associated Steatotic Liver Disease (MASLD) is a complex metabolic condition, the progression of which toward steatohepatitis can be explained by the 'two-hit' hypothesis: the first hit involves lipid accumulation, and the second hit involves inflammation and oxidative stress. In this study, we aimed to evaluate the protective effects of a combination of hydroxycitric acid and capsaicin (CHC) against high-fat diet (HFD)-induced MASLD in rats, specifically by targeting the mechanisms associated with both hits. To establish the experimental model, rats were fed a HFD for 16 weeks, followed by treatment with CHC for 6 weeks starting on day one of the 16th week of HFD feeding.
View Article and Find Full Text PDFHigh-Expansion Natural Composite Films for Controlled Delivery of Hydroxycitric Acid in Obesity Therapy.
Polymers (Basel)
June 2025
Department of Pharmaceutical Technology, Faculty of Pharmaceutical Sciences, Prince of Songkla University, Hat Yai, Songkhla 90112, Thailand.
Expandable films represent a promising gastroretentive drug delivery system, offering prolonged gastric retention and sustained drug release features particularly advantageous for obesity treatment. This study developed high-expansion films using konjac and various low glycemic index starches, including purple potato, brown rice, resistant, and red jasmine rice starches, in combination with chitosan and hydroxypropyl methylcellulose (HPMC) E15. Garcinia extract was incorporated into the films using the solvent casting technique.
View Article and Find Full Text PDFIn silico screening, ADMET analysis and computational simulation studies on Choisy phytoconstituents as prospective antibreast cancer agents: a critical appraisal of the neglected plant.
3 Biotech
July 2025
Department of Biochemistry, Era's Lucknow Medical College & Hospital, Era University, Sarfarazganj, Hardoi Road, Lucknow, UP 226003 India.
This study employed in silico methods to evaluate the antibreast cancer potential of three phytocomponents from garcinol, anthocyanin, and hydroxycitric acid against nine breast cancer-related protein targets. Molecular docking revealed that garcinol exhibited the strongest binding affinity for BRCA2 (BE - 7.1 kcal/mol, Kd 6.
View Article and Find Full Text PDFHydroxycitric acid inhibits ferroptosis and ameliorates benign prostatic hyperplasia by upregulating the Nrf2/GPX4 pathway.
World J Urol
May 2025
Kunming Medical University Sixth Affiliated Hospital (Yuxi People's Hospital), Yuxi City, Yunnan Province, China.
Purpose: Benign prostatic hyperplasia (BPH) poses a significant public health challenge, affecting a substantial portion of aging men worldwide. Current therapeutic options offer limited efficacy. The pathogenesis of BPH is multifactorial, involving ferroptosis, oxidative stress, and chronic inflammation.
View Article and Find Full Text PDFComparison of Morphology, Components, and Activity of Four Species of Sanghuangporus Mushrooms (Agaricomycetes).
Int J Med Mushrooms
April 2025
College of life science, the Northeast forestry university, Haerbin, China.
Sanghuangporus is a precious genus of medicinal mushroom and internationally recognized as one of the best medicinal species for anti-cancer effects. In this study, the morphology, functional components and activities of four species Sanghuangporus were evaluated and analyzed. The thickness, color, ring lines and density of Sanghuangporus fruiting bodies parasitic on different species of trees had certain differences.
View Article and Find Full Text PDF