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Multiple myeloma commonly involves the skeleton. Extraosseous disease is sometimes noticed involving various organs. We present a very unusual site of myeloma involvement in the thyroid gland and thyroid cartilage.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6011562 | PMC |
http://dx.doi.org/10.4103/ijnm.IJNM_48_18 | DOI Listing |
Front Endocrinol (Lausanne)
September 2025
Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, China.
Objective: This study aimed to investigate comorbidity patterns and potential pathogenic mechanisms in patients with Hashimoto's thyroiditis (HT).
Methods: Patients with HT who visited the outpatient clinic of the Thyroid Department at Dongzhimen Hospital, Beijing University of Chinese Medicine, between June 2021 and December 2024 were included. Association rule analysis and logistic regression analysis were performed using SPSS 25.
Cureus
August 2025
College of Medicine, King Saud University, Riyadh, SAU.
Background Subclinical hypothyroidism (SCH) in pregnancy poses serious maternal and fetal risks, including miscarriage, gestational diabetes, and neurodevelopmental impairment. Despite clear international guidelines like those from the American Thyroid Association (ATA), global practice remains inconsistent. In Saudi Arabia, where SCH prevalence among pregnant women is notably high (13%), there is limited national data on how closely physicians follow these guidelines.
View Article and Find Full Text PDFJ Appl Toxicol
September 2025
School of Public Health, Key Laboratory of Special Environmental and Health Research, Xinjiang Medical University, Urumqi, China.
Humans' exposure to arsenic (As) has been associated with the development of various diseases. Some health effects may be mediated by arsenic-induced toxicity to the thyroid and endocrine systems, but its underlying mechanisms remain unclear. The overall aim of our study was focused on using sodium arsenite (NaAsO)-exposed rats to investigate the involvement of the phosphatidylinositol 3-kinase (PI3K) and transcription factor NF-E2-related factor 2 (Nrf2) pathways in toxicity to the thyroid and endocrine systems.
View Article and Find Full Text PDFSci China Life Sci
September 2025
State Key Laboratory of Experimental Hematology, The Province and Ministry Co-sponsored Collaborative Innovation Center for Medical Epigenetics, Key Laboratory of Immune Microenvironment and Disease (Ministry of Education), Tianjin Medical University Cancer Institute and Hospital, Tianjin Key Labora
Histone arginine methylation by protein arginine methyltransferases (PRMTs) is crucial for transcriptional regulation and is implicated in cancers. Despite their therapeutic potential, some PRMTs present challenges as drug targets due to their context-dependent activities. Here, we demonstrate that hypoxia triggers the rapid condensation of PRMT2, which is essential for its histone H3R8 asymmetric dimethylation (H3R8me2a) activity.
View Article and Find Full Text PDFPediatrics
September 2025
Division of Emergency Medicine, Boston Children's Hospital, Department of Pediatrics, Harvard Medical School, Boston, Massachusetts.
Background And Objectives: There are recommendations against routine medical clearance testing for children evaluated in the emergency department (ED) for mental health concerns. Our objective was to determine variation, factors, and costs associated with medical clearance testing during ED encounters for mental health concerns.
Methods: We conducted a cross-sectional study of ED encounters among children aged 5 to 18 years who presented to 35 US children's hospitals for mental health concerns (2016-2023).