98%
921
2 minutes
20
Download full-text PDF |
Source |
---|---|
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5940736 | PMC |
http://dx.doi.org/10.1038/s41426-018-0080-7 | DOI Listing |
Cureus
August 2025
Department of Urology, Dammam Medical Complex, Dammam, SAU.
Testicular torsion is a urological emergency that occurs when the spermatic cord twists, cutting off blood supply to the testicle, and it requires immediate surgical intervention to prevent irreversible damage. Although it typically presents with sudden, severe scrotal pain and swelling, atypical presentations can complicate diagnosis and delay treatment. We report the case of a 25-year-old male who presented to the emergency department with a sudden onset of left lower abdominal pain and left inguinal swelling.
View Article and Find Full Text PDFFront Cell Dev Biol
August 2025
Reproductive Medical Center, The Second Hospital of Jilin University, Changchun, China.
The gut microbiota, comprising trillions of bacteria, fungi, and viruses, exists in symbiosis with the host. As the largest microbial ecosystem in the human body. The gut microbiota not only shapes the homeostasis of the intestinal microenvironment through gut-derived metabolites but also exerts regulatory effects on the functions of diverse tissues and organs throughout the body via the intricate "gut-distal organ axis" mechanism.
View Article and Find Full Text PDFFront Endocrinol (Lausanne)
September 2025
Department of Pharmacology, Wrocław Medical University, Wrocław, Poland.
Hypergonadotropic hypogonadism is usually caused by the impairment of the structure and function of the gonads, but there are cases caused by reduced stimulation by the follicle-stimulating hormone (FSH) as a result of abnormal variants of genes encoding the follicle-stimulating hormone or its receptor (FSHR). We present the case of an elite athlete with the c.2039A>G variant in one allele of the FSHR gene resulting in hypergonadotropic hypogonadism, low testicular volume, and reduced semen parameters, placing particular emphasis on the diagnostic process and the importance of correct diagnosis in the context of possible treatment with gonadotropins, which can significantly improve fertility, increase testosterone levels, and, in the case of athletes, obtain approval from the anti-doping organization for treatment that increases testosterone levels.
View Article and Find Full Text PDFFood Chem Toxicol
September 2025
Department of Human Anatomy, College of Medicine and Health Sciences, Afe Babalola University, Ado-Ekiti, Ekiti State, Nigeria.
Globally, the South Asian Cocktail (SAC), a substance of abuse, is becoming popular. The effects of SAC on male fertility are unknown; however, its component pharmaceuticals, such as codeine, rohypnol, and promethazine, have been linked to male infertility. Thus, this study assessed SAC's influence and putative mechanisms on male fertility among SAC consumers.
View Article and Find Full Text PDFToxicol Appl Pharmacol
September 2025
Department of Environmental Hygiene and Toxicology, School of Public Health, Wenzhou Medical University, Wenzhou 325035, China. Electronic address:
Phthalates (PEs) are widespread in environment, and human beings are unavoidably exposing to the mixture of PEs, which may induce male reproductive health risks. In order to investigate the mechanism of male reproductive injuries caused by the mixture of di-2-ethylhexyl phthalate, dibutyl phthalate and butyl benzyl phthalate (MPEs), male rats were orally exposed to 16 mg/kg/d MPEs (L-MPEs) and 450 mg/kg/d MPEs (H-MPEs) for 90 days, and the results showed that MPEs decreased the weights of testes, epididymis and periepididymis fat, decreased serum levels of male hormones, increased abnormal sperm rate, and caused testicular histopathological damages, such as atrophy and cavitation of seminiferous tubules, spermatids exfoliation, Leydig cells hyperplasia and accumulation of lipid droplets in the testicular interstitium. Testicular transcriptomic analysis identified 100 differently expressed genes (DEGs) in L-MPEs group and 10,880 DEGs in H-MPEs group, and these DEGs mainly involved in signaling pathways of focal adhesion, PI3K-Akt, AGE-RAGE, axon guidance, PPAR, MAPK and etc.
View Article and Find Full Text PDF