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Article Abstract
Background: Leptin () and LEP receptor () polymorphisms may be associated with the development of cancer.
Methods: In this study, we selected five functional and single-nucleotide polymorphisms (SNPs) and conducted a case-control study to determine the relationship of and polymorphisms with hepatocellular carcinoma (HCC) risk in Eastern Chinese Han population. There were 584 HCC cases and 923 cancer-free controls included in our study. HCC patients and controls were fully matched by age and sex. SNPscan™ genotyping method was used to analyze the genotyping of rs2167270 G>A, rs7799039 A>G, rs6588147 G>A, rs1137100 G>A, and rs1137101 G>A SNPs.
Results: We found that rs7799039 A>G and rs2167270 G>A polymorphisms were associated with the susceptibility of HCC in this population ( rs7799039 A>G: GG vs AA: adjusted odds ratio [OR]=2.03, 95% CI, 1.22-3.38, =0.006 and GG vs AA/AG: adjusted OR=1.97, 95% CI, 1.20-3.22, =0.007; rs2167270 G>A: AA vs GG: adjusted OR=2.03, 95% CI, 1.10-3.75, =0.024 and AA vs GG/GA: adjusted OR=2.01, 95% CI, 1.10-3.68, =0.023). However, rs6588147 G>A polymorphism decreased the risk of HCC (GA vs GG: adjusted OR=0.62, 95% CI, 0.45-0.86, =0.005 and AA/GA vs GG: adjusted OR=0.64, 95% CI, 0.47-0.88, =0.007).
Conclusion: This case-control study highlights that rs7799039 A>G and rs2167270 G>A polymorphisms increase the susceptibility to HCC; however, rs6588147 G>A polymorphism may be a protective factor for HCC in Eastern Chinese Han population.
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| http://dx.doi.org/10.2147/OTT.S153931 | DOI Listing |
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