Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
The endocannabinoid and opioid systems are two interplaying neurotransmitter systems that modulate drug abuse, anxiety, pain, cognition, neurogenesis and immune activity. Although they are involved in such critical functions, our understanding of endocannabinoid and opioid physiology remains limited, necessitating further studies, novel models and new model organisms in this field. Zebrafish (Danio rerio) is rapidly emerging as one of the most effective translational models in neuroscience and biological psychiatry. Due to their high physiological and genetic homology to humans, zebrafish may be effectively used to study the endocannabinoid and opioid systems. Here, we discuss current models used to target the endocannabinoid and opioid systems in zebrafish, and their potential use in future translational research and high-throughput drug screening. Emphasizing the high degree of conservation of the endocannabinoid and opioid systems in zebrafish and mammals, we suggest zebrafish as an excellent model organism to study these systems and to search for the new drugs and therapies targeting their evolutionarily conserved mechanisms.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.pnpbp.2018.03.024 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Neuropeptide S pathway in PTSD and neuropsychiatric disorders: A review.
Biomol Biomed
August 2025
Beijing Institute of Pharmacology and Toxicology, Beijing, China.
Post-traumatic stress disorder (PTSD) is a multidimensional illness that seldom occurs alone: roughly 80 % of patients also meet criteria for anxiety, depression, chronic pain, substance-use, eating or cognitive disorders. Converging genetic, neurochemical and behavioural findings implicate the neuropeptide S (NPS) system-acting through its G-protein-coupled NPS receptor (NPSR)-as a common regulator of these diverse phenotypes. This narrative review surveys studies published 2000-2024 in PubMed, Embase and Web of Science that examine NPS/NPSR involvement in core PTSD features and typical comorbidities.
View Article and Find Full Text PDFThe role of the endocannabinoid system in the mechanism of action of nonopioid analgesics.
Eur J Pharmacol
September 2025
Third Faculty of Medicine, Charles University, Ruska 2411, Praha 10-Vinohrady, 100 00, Czechia. Electronic address:
The endocannabinoid system (eCBS) plays a crucial role in pain modulation through its components, including endocannabinoids, cannabinoid receptors (CB and CB), and metabolic enzymes. Recent research highlights the interaction between the eCBS and non-opioid analgesics, including nonsteroidal anti-inflammatory drugs (NSAIDs), paracetamol, and pyrazolones. These agents may enhance endogenous endocannabinoid levels or influence eCBS signaling pathways, providing a multifaceted approach to pain relief.
View Article and Find Full Text PDFMice lacking the endocannabinoid-synthesizing enzyme NAPE-PLD exhibit sex-dependent dysregulations in responsiveness to oxycodone and a natural reward.
Neuropharmacology
November 2025
Department of Psychological and Brain Sciences, Indiana University, Bloomington, IN, 47405, United States; Program in Neuroscience, Indiana University, Bloomington, IN, 47405, United States; Gill Institute for Neuroscience, Indiana University, Bloomington, IN, 47405, United States. Electronic addres
The endogenous cannabinoid (endocannabinoid) and opioid systems are highly interconnected in the context of drug reward. Bioactive lipids known as N-acylethanolamines (NAEs), and, specifically, anandamide (AEA), influence several unwanted side effects of opioids, including dependence and tolerance. AEA undergoes degradation catalyzed by the enzyme fatty-acid amide hydrolase (FAAH), whereas the biosynthesis of AEA in vivo is catalyzed by the enzyme N-acyl phosphatidylethanolamine phospholipase-D (NAPE-PLD).
View Article and Find Full Text PDFThe Power of Movement: How Exercise Influences Chemotherapy-Induced Peripheral Neuropathy.
Biomedicines
May 2025
Unit of Experimental Biology, Department of Biomedicine, Faculty of Medicine, University of Porto, Alameda Prof. Hernâni Monteiro, 4200-319 Porto, Portugal.
As the number of cancer patients and survivors increases, we face a rising challenge: the long-term impact of the adverse effects of cancer treatment. One of the known adverse effects is chemotherapy-induced peripheral neuropathy (CIPN), which courses with pain complaints. The treatments of CIPN have reduced efficacy.
View Article and Find Full Text PDFThe role of the endogenous opioid system in modulating orthodontic-induced neurogenic inflammation of the dental pulp: A comprehensive review of the literature.
Int Endod J
August 2025
Endodontics Department, Universidad de San Carlos de, Guatemala City, Guatemala.
Background: Orthodontic forces may lead to neurogenic inflammation in the dental pulp by triggering the release of somatosensory neuropeptides such as Substance P (SP), Calcitonin gene-related peptide (CGRP) and Neurokinin A (NKA). In the vast majority of patients, acute symptoms are not triggered, probably due to the control of the neurogenic inflammatory process exerted by endogenous opioid systems.
Objective: This review aimed to assess the cellular and molecular mechanisms through which the endogenous opioid system modulates the orthodontic-induced neurogenic inflammation of the dental pulp and to identify potential mechanisms for endogenous control of pulp pain.