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The prevalence of HIV-infected people aged 50 years or older is increasing rapidly; the proportion will increase from 28% to 73% in 2030. In addition, HIV-infected individuals may be more vulnerable to age-related condition. There is growing evidence that the prevalence of comorbidities and other age-related conditions (geriatric syndromes, functional or neurocognitive/mental problems, polypharmacy, and social difficulties) is higher in the HIV-infected population than in their uninfected counterparts. However, despite the potential impact of this situation on health care, little information exists about the optimal clinical management of older HIV-infected people. Here we examine the age-related conditions in older HIV-infected persons and address clinical management according to author expertise and published literature. Our aim is to advance the debate about the most appropriate management of this population, including less well-studied aspects, such as frequency of screening for psychological/mental and social and functional capabilities.
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http://dx.doi.org/10.1155/2017/5897298 | DOI Listing |
Medicine (Baltimore)
September 2025
Department of Orthopaedics, Beijing Ditan Hospital Affiliated to Capital Medical University, Beijing, China.
Osteoporosis is a common metabolic bone disease characterized by decreased bone density and increased fracture risk. Human immunodeficiency virus (HIV) infection is considered one of the independent risk factors for osteoporosis, but its specific mechanisms are not yet clear. This study aims to explore the relationship between HIV infection and osteoporosis based on the National Health and Nutrition Examination Survey database and to analyze the impact of related clinical factors on bone density.
View Article and Find Full Text PDFPLoS Biol
September 2025
Department of Virology, Immunology & Microbiology, Boston University Chobanian & Avedisian School of Medicine, Boston, Massachusetts, United States of America.
Despite the success of antiretroviral therapy in suppressing plasma viremia in people living with human immunodeficiency virus type-1 (HIV-1), persistent viral RNA expression in tissue reservoirs is observed and can contribute to HIV-1-induced immunopathology and comorbidities. Infection of long-lived innate immune cells, such as tissue-resident macrophages and microglia may contribute to persistent viral RNA production and chronic inflammation. We recently reported that de novo cytoplasmic expression of HIV-1 intron-containing RNA (icRNA) in macrophages and microglia leads to MDA5 and MAVS-dependent innate immune sensing and induction of type I IFN responses, demonstrating that HIV icRNA is a pathogen-associated molecular pattern (PAMP).
View Article and Find Full Text PDFHIV AIDS (Auckl)
September 2025
Department of Respiratory Medicine, Beijing Ditan Hospital, Capital Medical University, Beijing, People's Republic of China.
Introduction: The advent of highly active antiretroviral therapy (HAART) has changed infection by human immunodeficiency virus (HIV) from an acute disease to a manageable chronic condition; however, pulmonary complications continue to affect patient quality of life. The goal of this research was to examine the link between CD4+ levels, viral load, and respiratory function in patients infected with HIV.
Methods: Patients were grouped as HIV-infected and non-infected (1:2 ratio).
Front Cell Infect Microbiol
September 2025
Fundació Lluita contra les Infeccions, Badalona, Spain.
Background: The intestinal microbiota composition has been linked to neurocognitive impairment in people with HIV (PWH). However, the potential interplay of microbial species and related metabolites, particularly in the context of an HIV cure strategy remains underexplored. The BCN02 trial evaluated the impact of romidepsin (RMD), used as a HIV-1 latency reversing agent and with reported beneficial neurological effects, combined with the MVA.
View Article and Find Full Text PDFRinsho Ketsueki
September 2025
Division of Hematopoiesis, Joint Research Center for Human Retrovirus Infection, Kumamoto University.
AIDS-related malignant lymphomas (ARL) are lymphomas that develop in association with HIV infection. Although the introduction of combination antiretroviral therapy (cART) has markedly improved the life expectancy of people living with HIV (PLWH), approximately one-third of PLWH, including some with well controlled disease, still die from HIV-associated malignancies. HIV itself is not tumorigenic, and most of these tumors are due to co-infection with oncogenic viruses.
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