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We report a large compilation of the internal validations of the probabilistic genotyping software STRmix™. Thirty one laboratories contributed data resulting in 2825 mixtures comprising three to six donors and a wide range of multiplex, equipment, mixture proportions and templates. Previously reported trends in the LR were confirmed including less discriminatory LRs occurring both for donors and non-donors at low template (for the donor in question) and at high contributor number. We were unable to isolate an effect of allelic sharing. Any apparent effect appears to be largely confounded with increased contributor number.
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http://dx.doi.org/10.1016/j.fsigen.2018.01.003 | DOI Listing |
Urol J
September 2025
Department of Child and Adolescent Psychiatry, Faculty of Medicine, Recep Tayyip Erdogan University, Rize, TURKIYE.
Purpose: This study aimed to investigate the genetic heterogeneity of primary monosymptomatic nocturnal enuresis (PMNE) and assess potential genetic variants contributing to its etiology.
Materials And Methods: A total of 92 children aged 5-15 years with a positive family history of PMNE were evaluated. All patients underwent detailed urological and nephrological assessments to exclude organic causes.
Rheumatol Int
September 2025
Division of Rheumatology, Department of Internal Medicine, Istanbul Faculty of Medicine, Istanbul University, Fatih, 34093, Istanbul, Turkey.
Behçet disease (BD) is a chronic, relapsing inflammatory disorder, and human leukocyte antigen (HLA)-B*51 is considered to be the strongest genetic susceptibility factor. The integrated stress response (ISR), defined by the eIF2α/ATF4 axis, is a signaling network that maintains protein homeostasis and regulates innate immunity in eukaryotic cells; pathological activation of this pathway can affect the immune response and cause various diseases. In this study, we aimed to investigate the role of the ISR signaling pathway in the pathogenesis of BD.
View Article and Find Full Text PDFSci Total Environ
September 2025
Jiangsu Key Laboratory of Atmospheric Environment Monitoring and Pollution Control, School of Environmental Science and Engineering, Nanjing University of Information Science and Technology, Nanjing 210044, China. Electronic address:
Sewage sludge has long been believed as an essential sink for microplastics (MPs), with concentrations up to 1380 particles/kg dry weight. Considering that MP residues in present sewage sludge are predominantly aged, their surface characteristics have been modified, with specific surface area ranging from 1 m/g to 5 m/g and a carbonyl index increasing from 0.2 to 1.
View Article and Find Full Text PDFJ Multidiscip Healthc
August 2025
Department of Pharmacy, Municipal Hospital Affiliated to Taizhou University, Taizhou, 318000, People's Republic of China.
Purpose: Cardiovascular and cerebrovascular diseases related to atherosclerosis represent a leading global health burden, contributing substantially to morbidity, disability, and premature mortality. The Ankle-Brachial Index (ABI) has emerged as a valuable non-invasive tool for screening peripheral artery disease and assessing the burden of systemic atherosclerosis. This bibliometric analysis aims to evaluate the research landscape, key contributors, and evolving trends in ABI and atherosclerosis studies.
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