Category Ranking

98%

Total Visits

921

Avg Visit Duration

2 minutes

Citations

20

Article Abstract

We report a large compilation of the internal validations of the probabilistic genotyping software STRmix™. Thirty one laboratories contributed data resulting in 2825 mixtures comprising three to six donors and a wide range of multiplex, equipment, mixture proportions and templates. Previously reported trends in the LR were confirmed including less discriminatory LRs occurring both for donors and non-donors at low template (for the donor in question) and at high contributor number. We were unable to isolate an effect of allelic sharing. Any apparent effect appears to be largely confounded with increased contributor number.

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.fsigen.2018.01.003DOI Listing

Publication Analysis

Top Keywords

contributor number
8
internal validation
4
validation strmix™
4
strmix™ multi
4
multi laboratory
4
laboratory response
4
response pcast
4
pcast report
4
report large
4
large compilation
4

Similar Publications

Regional Genetic Study: Monosymptomatic Nocturnal Enuresis and Array Technology.

Urol J

September 2025

Department of Child and Adolescent Psychiatry, Faculty of Medicine, Recep Tayyip Erdogan University, Rize, TURKIYE.

Purpose: This study aimed to investigate the genetic heterogeneity of primary monosymptomatic nocturnal enuresis (PMNE) and assess potential genetic variants contributing to its etiology.

Materials And Methods: A total of 92 children aged 5-15 years with a positive family history of PMNE were evaluated. All patients underwent detailed urological and nephrological assessments to exclude organic causes.

View Article and Find Full Text PDF

Integrated stress response in Behçet disease: expression analyses in peripheral blood and synovial monocytes.

Rheumatol Int

September 2025

Division of Rheumatology, Department of Internal Medicine, Istanbul Faculty of Medicine, Istanbul University, Fatih, 34093, Istanbul, Turkey.

Behçet disease (BD) is a chronic, relapsing inflammatory disorder, and human leukocyte antigen (HLA)-B*51 is considered to be the strongest genetic susceptibility factor. The integrated stress response (ISR), defined by the eIF2α/ATF4 axis, is a signaling network that maintains protein homeostasis and regulates innate immunity in eukaryotic cells; pathological activation of this pathway can affect the immune response and cause various diseases. In this study, we aimed to investigate the role of the ISR signaling pathway in the pathogenesis of BD.

View Article and Find Full Text PDF

The overlooked pathway: A systematic review on sewage sludge treatment as a critical secondary source of terrestrial micro(nano)plastics.

Sci Total Environ

September 2025

Jiangsu Key Laboratory of Atmospheric Environment Monitoring and Pollution Control, School of Environmental Science and Engineering, Nanjing University of Information Science and Technology, Nanjing 210044, China. Electronic address:

Sewage sludge has long been believed as an essential sink for microplastics (MPs), with concentrations up to 1380 particles/kg dry weight. Considering that MP residues in present sewage sludge are predominantly aged, their surface characteristics have been modified, with specific surface area ranging from 1 m/g to 5 m/g and a carbonyl index increasing from 0.2 to 1.

View Article and Find Full Text PDF

Purpose: Cardiovascular and cerebrovascular diseases related to atherosclerosis represent a leading global health burden, contributing substantially to morbidity, disability, and premature mortality. The Ankle-Brachial Index (ABI) has emerged as a valuable non-invasive tool for screening peripheral artery disease and assessing the burden of systemic atherosclerosis. This bibliometric analysis aims to evaluate the research landscape, key contributors, and evolving trends in ABI and atherosclerosis studies.

View Article and Find Full Text PDF