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Objective: The aim is to compare the retinal nerve fiber layer (RNFL) thickness of longitudinally extensive transverse myelitis (LETM) eyes without previous optic neuritis with that of healthy control subjects.
Methods: Over 20 LETM eyes and 20 normal control eyes were included in the study and subjected to optical coherence tomography to evaluate and compare the RNFL thickness.
Result: Significant RNFL thinning was observed at 8 o'clock position in LETM eyes as compared to the control eyes ( = 0.038). No significant differences were seen in other RNFL measurements.
Conclusion: Even in the absence of previous optic neuritis LETM can lead to subclinical axonal damage leading to focal RNFL thinning.
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http://dx.doi.org/10.4103/aian.AIAN_170_17 | DOI Listing |
Brain Sci
August 2025
Department of Neurology, New York University Grossman School of Medicine, 222 E 41st St., 14th Floor, New York, NY 10017, USA.
: Downbeat nystagmus (DBN) is an ocular motor disorder characterized by persistent to-and-fro eye movements with a slow phase directed upwards and a corrective fast phase downwards. DBN in the context of myelin oligodendrocyte glycoprotein-associated disorder (MOGAD) represents a rare clinical presentation. : A 24-year-old male with MOGAD presented with DBN, status epilepticus, and longitudinally extensive transverse myelitis (LETM).
View Article and Find Full Text PDFNeurol Sci
September 2025
Department of Neurology, Beijing Tongren Hospital, Capital Medical University, Beijing, 100176, China.
Background: We present a case of a patient diagnosed with optic neuritis (ON) and longitudinally extensive transverse myelitis (LETM) following Mycoplasma pneumoniae (M.pneumoniae) pneumonia.
Methods: A 60-year-old male, 16 days post-M.
Cureus
May 2023
Neurology, King Fahad General Hospital, Jeddah, SAU.
Neuromyelitis optica spectrum disorder (NMOSD) is a demyelinating central nervous system disease commonly presenting with optic neuritis and transverse myelitis. Its pathology is mediated by serum aquaporin 4 immunoglobulin G (AQP4-IgG) and myelin oligodendrocyte glycoprotein (MOG) antibodies. It can present in a relapsing and monophasic pattern and is diagnosed using the diagnostic criteria published in 2015 by the international panel on neuromyelitis optica (NMO) diagnosis.
View Article and Find Full Text PDFRom J Ophthalmol
November 2022
Department of Ophthalmology, Armed Forces Medical College, Pune, India.
Infectious atypical optic neuritis (AON), like tubercular, is a vision threatening condition with phenotypic overlap with Neuromyelitis Optica Spectrum Disorder (NMOSD). The overlapping neurological manifestations and negative AQP4-Ab-assay make it difficult to discover the primary cause of neuritis. We report two paediatric cases with NMOSD that did not fulfil the diagnostic criteria.
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