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The smallest subset of items from the 30-item Checklist for Autism Spectrum Disorder (CASD) that differentiated 607 referred children (3-17 years) with and without autism with 100% accuracy was identified. This 6-item subset (CASD-Short Form) was cross-validated on an independent sample of 397 referred children (1-18 years) with and without autism and on data from 1417 children in the CASD standardization sample and 1052 children in the CASD normative sample, resulting in 98.5, 97.6, and 99.8% diagnostic accuracy, respectively. Diagnostic agreement was high between the CASD-Short Form and the Autism Diagnostic Interview-Revised (96%), and the Child Autism Rating Scale (98%). Diagnostic accuracy for the CASD-SF was similar to accuracy for the 30-item CASD full form.
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http://dx.doi.org/10.1007/s10803-017-3401-0 | DOI Listing |
Alpha Psychiatry
August 2025
State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, 100875 Beijing, China.
Background: Autism spectrum disorder (ASD) is a multifaceted neurodevelopmental disorder marked by impaired interactions and restricted interests, the pathophysiology of which is not fully understood. The current study explored the potential therapeutic effects of transcranial direct current stimulation (tDCS) on the neurophysiological aspects of ASD, specifically focusing on the brain's excitatory/inhibitory (E/I) balance and behavioral outcomes, providing scientific guidance for ASD intervention.
Methods: Forty-two children with ASD were randomly divided into either an active tDCS or sham tDCS group.
Front Pediatr
August 2025
Department of Pharmacy, Children's Hospital of Hebei Province, Shijiazhuang, Hebei, China.
Background: This study intended to explore the levels of 25(OH)D and 25(OH)D in children with autism spectrum disorder (ASD) and analyzed the correlation between 25(OH)D, 25(OH)D levels and ASD core symptoms, children development.
Methods: A total of 208 children with ASD who were diagnosed in hospital from January 2021 to December 2023 were selected as the ASD group. 208 children for routine physical examination were selected as the control group.
J Intellect Disabil Res
September 2025
Department of General Practice, Intellectual Disability Medicine Research, Erasmus MC, University Medical Center, Rotterdam, the Netherlands.
Background: Off-label antipsychotic use in people with intellectual disabilities and challenging behaviour is high. Antipsychotic withdrawal is recommended, but attempts are often unsuccessful. This study aimed to develop and internally validate a prediction model that provides insight into predicting factors for unsuccessful (i.
View Article and Find Full Text PDFFront Psychiatry
August 2025
Department of Child and Adolescent Psychiatry, Faculty of Medicine Hospital, Necmettin Erbakan University, Konya, Türkiye.
Introduction: The aim of this study is to investigate, using magnetic resonance imaging (MRI), the optic nerve diameter, morphometric characteristics of the optic chiasm (OC), volumes of the lateral, third, and fourth ventricles, as well as the volumes of the corpus callosum (CC) and choroid plexus (CP) in children with autism spectrum disorder (ASD), and to compare these findings with those of a typically developing (TD) control group. Additionally, the study seeks to evaluate the impact of these neuroanatomical parameters on autism symptom severity and sensory sensitivity.
Methods: This study included 111 children with ASD and 143 TD control children, aged between 5 and 13 years.
Front Psychiatry
August 2025
Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Background: Autism Spectrum Disorder (ASD) is characterized by social deficits and restricted, repetitive behaviors, with fewer than 10% achieving independent adulthood. Immersive virtual reality (IVR) provides a novel training approach through interactive and realistic environments. This study developed an IVR system to enhance adaptive skills in children and adolescents with high-functioning ASD.
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