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Clinical, Radiologic, and Optical Coherence Tomographic Features of Pediatric Acute Disseminated Encephalomyelitis: Comparison of Myelin Oligodendrocyte Glycoprotein Antibody-Positive and -Negative Cases.
Pediatr Neurol
October 2025
Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas; Department of Neurology, University of Texas Southwestern Medical Center, Dallas, Texas.
Background: Acute disseminated encephalomyelitis (ADEM) typically presents as a monophasic demyelinating disorder associated with multifocal neurological symptoms and encephalopathy in children. Myelin oligodendrocyte glycoprotein antibody (MOG-IgG) is detected in a subset of patients and may be linked to recurrence risk. This study evaluated the clinical, radiologic, and optic coherence tomographic (OCT) features of children with ADEM based on MOG-IgG serostatus.
View Article and Find Full Text PDFClinical characteristics and associated factors of pediatric acute disseminated encephalomyelitis patients with MOG antibodies: a retrospective study in Hangzhou, China.
BMC Neurol
November 2022
Department of Child Psychology, Children's Hospital, School of Medicine, Zhejiang University, 3333 Binsheng Road, Binjiang District, Hangzhou City, 310052, P.R. China.
Background: To explore the clinical characteristics and related factors of children with acute disseminated encephalomyelitis (ADEM) with positive anti-myelin oligodendrocyte glycoprotein (MOG) antibody.
Methods: A retrospective study was conducted and enrolled pediatric ADEM patients who underwent serum MOG antibody detection from May 2017 to August 2020. The patients were divided into two groups: MOG- immunoglobulin G (IgG) positive (n = 35) and MOG-IgG negative (n = 50).
Anti-myelin oligodendrocyte glycoprotein antibodies in a girl with good recovery after five episodes of prior idiopathic optic neuritis.
Am J Ophthalmol Case Rep
June 2021
Clinic of Optic Neuritis, The Danish Multiple Sclerosis Center (DMSC), Department of Neurology, Rigshospitalet - Glostrup, University of Copenhagen, Valdemar Hansens Vej 13, 2600, Glostrup, Denmark.
Purpose: To describe the clinical, radiological, immunological and electrophysiological features of a myelin oligodendrocyte glycoprotein (MOG)-IgG positive girl with five prior episodes of idiopathic bilateral optic neuritis (ON).
Observations: We report a Danish girl who has been followed by pediatricians and pediatric neurologists since the age of 10 with recurrent episodes of idiopathic bilateral ON. Since the age of 15 there has been no recurrence of ON, and the patient has been thoroughly investigated for Multiple Sclerosis (MS) several times, but with negative findings.
Diagnostic features of initial demyelinating events associated with serum MOG-IgG.
J Neuroimmunol
July 2020
Department of Neuroscience, Biomedicine and Movement Sciences, University of Verona and Neurology Unit B, Azienda Ospedaliera Universitaria Integrata Verona, Verona, Italy.
Background: Myelin oligodendrocyte glycoprotein (MOG)-IgG associated disorders are increasingly recognized as a distinct disease entity. However, diagnostic sensitivity and specificity of serum MOG-IgG as well as recommendations for testing are still debated.
Materials And Methods: Between October 2015 and July 2017 we tested serum MOG-IgG in 91 adult patients (49 females) with a demyelinating event (DE) not fulfilling 2010 McDonald criteria for MS at sampling, negative for neuromyelitis optica (NMO)-IgG and followed-up for at least 12 months.
MOG-IgG-positive multifocal myelitis with intrathecal IgG synthesis as a spectrum associated with MOG autoimmunity: Two case reports.
J Neurol Sci
November 2017
Department of Neurology, Kitasato University School of Medicine, Sagamihara, Japan. Electronic address: