Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Objective: To investigate the effectiveness of a new individualized contrast medium injection protocol for enhanced liver CT scan.
Methods: 324 patients who underwent plain and dual phase enhanced liver CT were randomly assigned to 2 groups: G1 ( = 224, individualized contrast medium injection protocol); G2 ( = 100, standard contrast medium injection with a dose of 1.5 ml/kg). CT values and ΔHU (CT values difference between plain and enhanced CT) of liver parenchyma and tumor-liver contrast (TLC) during hepatic arterial phase (HAP) and portal venous phase (PVP) and contrast medium dose were measured. The tumor conspicuity of hepatocellular carcinoma (HCC) between two groups was independently evaluated by two radiologists.
Results: The mean contrast medium dose of G1 was statistically lower than that of G2. There were no significantly statistical differences in CT values and ΔHU of liver parenchyma during HAP, TLC values during HAP, and PVP between two groups. The CT values and ΔHU of liver parenchyma during PVP of G2 were significantly higher than those of G1. Two independent radiologists were both in substantial conformity in grading tumor conspicuity.
Conclusion: Using the individually optimized injection protocol might reduce contrast medium dose without impacting on the imaging quality in enhanced liver CT.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5612702 | PMC |
| http://dx.doi.org/10.1155/2017/7350429 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Mumps virus infection triggers early pro-inflammatory responses and impairs Leydig and Sertoli cell function in an ex vivo human testis model.
Hum Reprod
September 2025
Institut National de la Santé et de la Recherche Médicale, Ecole des Hautes Etudes en Santé Publique, Institut de recherche en santé, environnement et travail, Université de Rennes-UMR_S1085, Rennes, France.
Study Question: What is the direct effect of mumps virus (MuV) replication within the human testis on the tissue innate immune responses and testicular cell functions?
Summary Answer: MuV induces an early pro-inflammatory response in the human testis ex vivo and infects both Leydig cells and Sertoli cells, which drastically alters testosterone and inhibin B production.
What Is Known Already: Despite widespread vaccination efforts, orchitis remains a significant complication of MuV infection, especially in young men, which potentially results in infertility in up to 87% of patients with bilateral orchitis. Our understanding of MuV pathogenesis in the human testis has been limited by the lack of relevant animal models, impairing the development of effective treatments.
Clinical Doses of Gadodiamide Have No Damaging Effects on Cochlear Tissue In Vitro and In Vivo.
Neurotoxicology
September 2025
Department of Otolaryngology Head and Neck Surgery, The Third People's Hospital of Chengdu, The Affiliated Hospital of Southwest Jiaotong University, Chengdu 610031, China. Electronic address:
Gadolinium-based contrast agents (GBCAs) are widely used in systemic magnetic resonance imaging (MRI) and can be employed in otology to evaluate endolymphatic hydrops in patients with Ménière's disease. Given the heavy metal properties of gadolinium and its tendency to deposit in tissues, it is essential to assess its ototoxic risk. We evaluated the ototoxicity of gadodiamide using in vitro and in vivo models.
View Article and Find Full Text PDFGenetically encoded FerriTag as a specific label for cryo-electron tomography.
Structure
September 2025
Institute of Anatomy, University of Bern, 3012 Bern, Switzerland. Electronic address:
Cryo-electron tomography (cryoET) provides 3D datasets of organelles and proteins at nanometer and sub-nanometer resolution. However, locating target proteins in live cells remains a significant challenge. Conventional labeling methods, such as fluorescent protein tagging and immunogold labeling, are unsuitable for small structures in vitrified samples at molecular resolution.
View Article and Find Full Text PDFMomentum, volume and investor sentiment study for u.s. technology sector stocks-A hidden markov model based principal component analysis.
PLoS One
September 2025
Department of Economics, Cornell University, Ithaca, United States of America.
In this paper, we study the impact of momentum, volume and investor sentiment on U.S. tech sector stock returns using Principal Component Analysis-Hidden Markov Model (PCA-HMM) methodology.
View Article and Find Full Text PDFUltrasound Autofocusing: Common Midpoint Phase Error Optimization via Differentiable Beamforming.
IEEE Trans Med Imaging
September 2025
In ultrasound imaging, propagation of an acoustic wavefront through heterogeneous media causes phase aberrations that degrade the coherence of the reflected wavefront, leading to reduced image resolution and contrast. Adaptive imaging techniques attempt to correct this phase aberration and restore coherence, leading to improved focusing of the image. We propose an autofocusing paradigm for aberration correction in ultrasound imaging by fitting an acoustic velocity field to pressure measurements, via optimization of the common midpoint phase error (CMPE), using a straight-ray wave propagation model for beamforming in diffusely scattering media.
View Article and Find Full Text PDF