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Sequence-definable polymers are seen as a prerequisite for design of future materials, with many polymer scientists regarding such polymers as the holy grail of polymer science. Recombinant proteins are sequence-defined polymers. Proteins are dictated by DNA templates and therefore the sequence of amino acids in a protein is defined, and molecular biology provides tools that allow redesign of the DNA as required. Despite this advantage, proteins are underrepresented in materials science. In this publication we investigate the advantages and limitations of using proteins as templates for rational design of new materials.
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http://dx.doi.org/10.1016/j.jsb.2017.10.012 | DOI Listing |
Sci Adv
September 2025
Applied Mechanics Laboratory, Department of Engineering Mechanics, Tsinghua University, Beijing 100084, P.R. China.
Bioinspired network designs are widely exploited in biointegrated electronics and tissue engineering because of their high stretchability, imperfection insensitivity, high permeability, and biomimetic J-shaped stress-strain responses. However, the fabrication of three-dimensionally (3D) architected electronic devices with ordered constructions of network microstructures remains challenging. Here, we introduce the tensile buckling of stacked multilayer precursors as a unique route to 3D network materials with regularly distributed 3D microstructures.
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September 2025
Department of Electrical and Computer Engineering, National University of Singapore, Singapore 117583, Singapore.
Embodied intelligence in soft robotics offers unprecedented capabilities for operating in uncertain, confined, and fragile environments that challenge conventional technologies. However, achieving true embodied intelligence-which requires continuous environmental sensing, real-time control, and autonomous decision-making-faces challenges in energy management and system integration. We developed deformation-resilient flexible batteries with enhanced performance under magnetic fields inherently present in magnetically actuated soft robots, with capacity retention after 200 cycles improved from 31.
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September 2025
State Key Laboratory for Manufacturing System Engineering, State Industry-Education Integration Center for Medical Innovations, International Joint Laboratory for Micro/Nano Manufacturing and Measurement Technologies, Shaanxi Innovation Center for Special Sensing and Testing Technology in Extreme En
Continuous monitoring of cardiovascular vital signs can reduce the incidence and mortality of cardiovascular diseases, yet cannot be implemented by current technologies because of device bulkiness and rigidity. Here, we report self-adhesive and skin-conformal ultrasonic transducer arrays that enable wearable monitoring of multiple hemodynamic parameters without interfering with daily activities. A skin-adaptive focused ultrasound method with rational array design is proposed to implement measurement under wide ranges of skin curvatures and depths with improved sensing performances.
View Article and Find Full Text PDFBioinformatics
September 2025
Computational Health Center, Helmholtz Center Munich, Neuherberg, 85764, Germany.
Motivation: Recent pandemics have revealed significant gaps in our understanding of viral pathogenesis, exposing an urgent need for methods to identify and prioritize key host proteins (host factors) as potential targets for antiviral treatments. De novo generation of experimental datasets is limited by their heterogeneity, and for looming future pandemics, may not be feasible due to limitations of experimental approaches.
Results: Here we present TransFactor, a computational framework for predicting and prioritizing candidate host factors using only protein sequence data.
Chem Soc Rev
September 2025
State Key Laboratory of Crystal Materials, School of Chemistry and Chemical Engineering, Shandong University, Jinan 250100, China.
Understanding the excited-state dynamics of atomically precise coinage metal nanoclusters (CMNCs) is pivotal for elucidating their photoluminescence (PL) mechanisms and rationally tuning emission properties-particularly in the near-infrared (NIR) region, where CMNC-based nanomaterials have tremendous potential for biomedical and optoelectronic applications. This review presents a systematic and comprehensive account of recent advances in investigating the excited-state dynamics and PL mechanisms of NIR-emitting CMNCs with atomic precision, leveraging the synergistic integration of time-resolved spectroscopy and time-dependent density functional theory (TD-DFT) calculations. Distinct from previous reviews that offer a broad survey of CMNC properties, the present review focuses specifically on intrinsic factors, highlighting molecular vibrational features and electronic structure modulation as key determinants of NIR emission.
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