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http://dx.doi.org/10.3389/fpsyg.2017.01767 | DOI Listing |
CNS Drugs
September 2025
Global Health Neurology Lab, Sydney, NSW, 2150, Australia.
Acute ischemic stroke (AIS) remains a leading cause of mortality and long-term disability globally, with survivors at high risk of recurrent stroke, cardiovascular events, and post-stroke dementia. Statins, while widely used for their lipid-lowering effects, also possess pleiotropic properties, including anti-inflammatory, endothelial-stabilizing, and neuroprotective actions, which may offer added benefit in AIS management. This article synthesizes emerging evidence on statins' dual mechanisms of action and evaluates their role in reducing recurrence, improving survival, and mitigating cognitive decline.
View Article and Find Full Text PDFS Afr Fam Pract (2004)
September 2025
School of Medicine, Faculty of Health Sciences, Nelson Mandela University, Gqeberha.
No abstract available.
View Article and Find Full Text PDFEssays Biochem
September 2025
Institute of Functional Nano & Soft Materials (FUNSOM), Soochow University, Suzhou, 215123, China.
The intricate regulation of the immune system, maintaining equilibrium between pathogen defense and self-tolerance, is fundamental to health. Disruptions in this delicate balance underlie a vast spectrum of human diseases, extending beyond oncology to encompass autoimmune disorders, chronic inflammatory conditions, infectious diseases, allergies, and hypertension. While traditional therapies often rely on broad immunosuppression or direct pathogen eradication, the rapidly evolving field of immunomodulation offers a nuanced alternative: precisely calibrating immune responses to restore homeostasis or achieve targeted defense.
View Article and Find Full Text PDFFood Res Int
November 2025
Department of Food Science and Nutrition, Faculty of Food Engineering, University of Campinas, Campinas, SP, Brazil. Electronic address:
The consumption of water of low microbiological quality can be detrimental and may cause significant health issues. Thus, amplicon sequencing can be an advantageous method to observe bacterial diversity in water. This study aimed to understand the complex bacterial communities present in natural mineral water packaged in 20 L returnable containers through amplicon sequencing.
View Article and Find Full Text PDFEur J Neurol
September 2025
Neuroimaging Research Unit, Division of Neuroscience, IRCCS San Raffaele Scientific Institute, Milan, Italy.
Background: Frontotemporal dementia (FTD) encompasses diverse clinical phenotypes, primarily characterized by behavioral and/or language dysfunction. A newly characterized variant, semantic behavioral variant FTD (sbvFTD), exhibits predominant right temporal atrophy with features bridging behavioral variant FTD (bvFTD) and semantic variant primary progressive aphasia (svPPA). This study investigates the longitudinal structural MRI correlates of these FTD variants, focusing on cortical and subcortical structural damage to aid differential diagnosis and prognosis.
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