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Article Abstract
Voltage-dependent Ca channels (VGCC) represent the principal source of Ca ions driving evoked neurotransmitter release at presynaptic boutons. In mammals, presynaptic Ca influx is mediated mainly via P/Q-type and N-type VGCC, which differ in their properties. Changes in their relative contributions tune neurotransmission both during development and in Hebbian plasticity. However, whether this represents a functional motif also present in other forms of activity-dependent regulation is unknown. Here, we study the role of VGCC in homeostatic plasticity (HSP) in mammalian hippocampal neurons using optical techniques. We find that changes in evoked Ca currents specifically through P/Q-type, but not N-type, VGCC mediate bidirectional homeostatic regulation of both neurotransmitter release efficacy and the size of the major synaptic vesicle pools. Selective dependence of HSP on P/Q-type VGCC in mammalian terminals has important implications for phenotypes associated with P/Q-type channelopathies, including migraine and epilepsy.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5643522 | PMC |
| http://dx.doi.org/10.1016/j.celrep.2017.09.061 | DOI Listing |
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