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Objective: The aim of this trial was to determine whether Flotrac Vigileo™ (FV™) provides a reliable representation of the hemodynamic state of a cardiac surgical patient population when compared to pulmonary artery catheter (PAC) and echocardiography in the peril-operative period.
Design: This was a prospective observational trial comparing perioperative hemodynamic states using transesophageal echocardiography (TEE), transthoracic echocardiography (TTE), FV™ and PAC during and post cardiothoracic surgery.
Setting: Tertiary regional hospital Intensive Care Unit (ICU).
Participants: 50 consecutive adult cardiothoracic patients with written consent provided.
Intervention: Comparison of the perioperative hemodynamic states using echocardiography, FV™ and PAC was performed. Evaluation of the hemodynamic state (HDS) was performed using TEE, TTE, PAC and FV™ during and after cardiac surgery. Data were compared between the three hemodynamic assessment modalities.
Main Outcome Measure: Predicted hemodynamic state.
Results: FV™ and PAC were shown to correlate poorly with TEE/TTE assessment of the hemodynamic state. Both PAC and FV™ showed significant discordance with echocardiographic assessment of the hemodynamic state.
Conclusions: In this trial, FV™ and PAC were shown to agree poorly with TTE/TEE assessment of the HDS in an adult cardiothoracic population. Agreement between the FV™ and PAC was also poor. Caution is recommended in interpreting isolated hemodynamic monitoring data. All hemodynamic monitoring devices have inherent sources of error. Caution is advised in interpreting any single device or measurement as a gold standard. We suggest that hemodynamic measuring devices such as FV™/PAC may act as triggers for a global hemodynamic assessment including consideration of TTE/TEE.
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http://dx.doi.org/10.4103/2229-5151.214411 | DOI Listing |
J Oral Pathol Med
September 2025
Postgraduate Program in Dentistry and Health, School of Dentistry, Universidade Federal da Bahia, Salvador, Bahia, Brazil.
Purpose: Polymorphous adenocarcinoma of the salivary gland is characterized by cellular uniformity associated with a variety of morphological growth patterns, a fact that makes its diagnosis challenging. Therefore, the identification of genetic alterations and signaling pathways emerges as a tool for elucidation of the pathogenesis of this tumor and accurate differential diagnosis. The aim of this study was to assess mutations in the PRKD1 gene and in protein components of the HH pathway (SHH, IHH, SMO, and GLI-1) in cases of polymorphous adenocarcinoma of the salivary gland.
View Article and Find Full Text PDFJ Physician Assist Educ
September 2025
Rachel Ditoro, EdD, MSPAS, PA-C, is a professor, program director of Salus at Drexel University PA Program, at Drexel University, Elkins Park, Pennsylvania.
Introduction: Physician assistant programs use summative evaluations to assess near graduates, with many using the PA Education Association (PAEA) End of Curriculum (EOC) exam to assess the medical knowledge component. Accurate identification of those students at risk of low Physician Assistant National Certifying Examination (PANCE) performance is imperative. The purpose of this study was to evaluate the relationship between the outcomes of the PAEA EOC exam and the PANCE.
View Article and Find Full Text PDFLancet Reg Health West Pac
September 2025
Department of Neurosurgery, West China Hospital, Sichuan University, Chengdu, China.
Background: There is ongoing controversy as to whether surgical intervention to haematoma evacuation benefits patients with acute intracerebral haemorrhage (ICH). This study aimed to evaluate the association of surgical intervention to evacuate the haematoma and 6-month functional outcome in participants of the third Intensive Care Bundle with Blood Pressure Reduction in Acute Cerebral Haemorrhage Trial (INTERACT3).
Methods: This was a secondary analysis of INTERACT3, which enrolled adults (age ≥18 years) spontaneous ICH patients within 6 h after onset.
ERJ Open Res
September 2025
Department of Respiratory Diseases, Bichat-Claude Bernard Hospital, Paris, France.
https://bit.ly/4bY6LMc.
View Article and Find Full Text PDFAsia Pac J Clin Oncol
September 2025
Faculty of Medicine, Department of Radiation Oncology, Dokuz Eylul University, Izmir, Türkiye.
Purpose: We aimed to analyze our radiotherapy protocol by evaluating its effect on recurrence patterns and survival outcomes.
Methods: We assessed 69 patients diagnosed with IDH-wild-type glioblastoma who underwent chemoradiotherapy at our institution from January 2014 to January 2021. A high-risk clinical target volume (CTV) was created with a 1 cm margin in all directions from the GTV, while a low-risk clinical target volume (CTV) was established with a 2 cm margin.