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Article Abstract
The enantioselective construction of densely functionalized cyclopentene bearing contiguous three stereocenters has been a challenging task in organic synthesis. Herein, we present a phoshine-catalyzed highly regio-, diastereo- and enantioselective [3 + 2] cycloaddition of γ-substituted allenoates with β-perfluoroalkyl enones, delivering a wide range of densely functionalized perfluoroalkylated cyclopentenes with three contiguous chiral stereocenters.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5590097 | PMC |
| http://dx.doi.org/10.1039/c7sc01432e | DOI Listing |
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