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Article Abstract
Some novel (phenyl-diazenyl)phenols (-) were designed and synthesized to be evaluated for their antibacterial activity. Starting from an active previously-synthesized azobenzene chosen as lead compound, we introduced some modifications and optimization of the structure, in order to improve solubility and drug conveyance. Structures of all newly-synthesized compounds were confirmed by ¹H nuclear magnetic resonance (NMR), mass spectrometry, and UV-Vis spectroscopy. Antibacterial activity of the new compounds was tested with the dilution method against the bacteria strains , , , and PAO1. All the compounds were selectively active against Gram-positive bacteria. In particular, compounds , , and showed the highest activity against and , reaching remarkable MIC values of 4 μg/mL and 8 μg/mL. The relationship between antimicrobial activity and compound structure has suggested that the presence of hydroxyl groups seems to be essential for antimicrobial activity of phenolic compounds.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6152091 | PMC |
| http://dx.doi.org/10.3390/molecules22081372 | DOI Listing |
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