Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Objective: Poor asthma control in children is related to impaired patient-reported outcomes (PROs; eg, fatigue, depressive symptoms, anxiety), but less well studied is the effect of PROs on children's school performance and sleep outcomes. In this study we investigated whether the consistency status of PROs over time affected school functioning and daytime sleepiness in children with asthma.
Methods: Of the 238 children with asthma enrolled in the Patient-Reported Outcomes Measurement Information System (PROMIS) Pediatric Asthma Study, 169 children who provided survey data for all 4 time points were used in the analysis. The child's PROs, school functioning, and daytime sleepiness were measured 4 times within a 15-month period. PRO domains included asthma impact, pain interference, fatigue, depressive symptoms, anxiety, and mobility. Each child was classified as having poor/fair versus good PROs per meaningful cut points. The consistency status of each domain was classified as consistently poor/fair if poor/fair status was present for at least 3 time points; otherwise, the status was classified as consistently good. Seemingly unrelated regression was performed to test if consistently poor/fair PROs predicted impaired school functioning and daytime sleepiness at the fourth time point.
Results: Consistently poor/fair in all PRO domains was significantly associated with impaired school functioning and excessive daytime sleepiness (Ps < .01) after controlling for the influence of the child's age, sex, and race/ethnicity.
Conclusions: Children with asthma with consistently poor/fair PROs are at risk of poor school functioning and daytime sleepiness. Developing child-friendly PRO assessment systems to track PROs can inform potential problems in the school setting.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5673502 | PMC |
| http://dx.doi.org/10.1016/j.acap.2017.07.010 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Molecular Engineering Empowers Phenanthraquinone Organic Cathodes with Exceptional Cycling Stability for Lithium- and Aqueous Zinc-Ion Batteries.
Adv Sci (Weinh)
September 2025
School of Materials Science and Engineering, Tianjin Key Laboratory of Composite and Functional Materials, State Key Laboratory of Advanced Materials for Intelligent Sensing, Tianjin University, Tianjin, 300072, China.
Organic electrode materials have garnered great attention in recent years, owing to their resource sustainability, structural diversity, and superior compatibility with various ionic species. Among them, quinone-based compounds have attracted particular interest. Notably, compared with para-quinone analogs (e.
View Article and Find Full Text PDFOne-Step Radical α-α Coupling Accesses Helical Near-Infrared 3-Pyrrolyl Boron Dipyrromethene Dimers.
Org Lett
September 2025
Department of Chemistry, Indian Institute of Techology Bombay, Powai, Mumbai 400076, India.
The direct α-α coupling of 3-pyrrolyl boron dipyrromethenes (BODIPYs) affords helical near-infrared (NIR)-active dimers in one step via a radical Pd-catalyzed process. X-ray analysis reveals Z-type helical packing stabilized by π-π stacking and hydrogen-bonding interactions. These dimers showed pronounced bathochromic absorption shifts compared to monomers and solvent-dependent charge-transfer bands up to 905 nm with fluorescence quenching.
View Article and Find Full Text PDFDirect -Azidomethylation of Thiols with -Azidomethyldisulfonimides.
Org Lett
September 2025
United Graduate School of Drug Discovery and Medical Information Sciences, Gifu University, 1-1 Yanagido, Gifu 501-1193, Japan.
A direct azidomethylation reaction at the sulfur atoms of thiols with -azidomethyldisulfonimides is presented, providing a facile and efficient approach for the synthesis of azidomethylated compounds with broad substrate scope and mild reaction conditions. Under optimized conditions using -azidomethyl-bis(4-trifluoromethylbenzene)sulfonimide as the azidomethyl source, various aliphatic and aromatic thiols furnish the corresponding -azidomethyl compounds in moderate to high yields. The reaction proceeds selectively at the mercapto group, even in substrates bearing polar functional groups.
View Article and Find Full Text PDFGuishen-erxian Decoction can improve ovarian function in rats with premature ovarian failure by inhibiting oxidative stress and granulosa cell DNA fragmentation mediated by the PI3K/Akt/FOXO3a pathway.
Histol Histopathol
September 2025
Center for Experimental Teaching, School of Pharmacy, Guangzhou Medical University, Guangzhou, China.
Background: The aim of this study was to establish a rat model of premature ovarian failure (POF) with cyclophosphamide (CTX), and explore the molecular basis of POF and the mechanism of Guishen-Erxian Decoction (GSEXD) to improve POF from the perspective of oxidative stress regulation of ovarian granulosa cell (OGC) DNA fragmentation.
Method: The study utilized SD rats to establish a POF model via CTX. Rats were divided into Control, POF group, three GSEXD dosage groups (low, medium, high), and a GSEXD+PI3K agonist group to assess GSEXD's therapeutic effects on oxidative stress, DNA fragmentation and ovarian damage.
Neck flexion weakness predicts respiratory dysfunction in amyotrophic lateral sclerosis.
Amyotroph Lateral Scler Frontotemporal Degener
September 2025
Brain and Nerve Research Centre, Concord Clinical School, University of Sydney, Concord Hospital, Sydney, Australia.
: Neck flexion (NF) weakness is a frequently observed clinical feature in amyotrophic lateral sclerosis (ALS), particularly in advanced disease. The aim of the present study was to assess whether NF weakness could be a clinical biomarker for development of respiratory dysfunction. : Sixty-two ALS patients were prospectively recruited at Brain and Nerve Research Center.
View Article and Find Full Text PDF