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A new cyclic depsipeptide, rakicidin F (1), along with the known compound rakicidin C (2), was isolated from the fermentation broth of the marine sponge-derived actinomycete strain Streptomyces sp. GKU 220. Their structures were elucidated by interpreting the HRFABMS and NMR spectroscopic data. Rakicidin F (1) showed growth inhibitory activity against bacteria.The Journal of Antibiotics advance online publication, 2 August 2017; doi:10.1038/ja.2017.92.
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http://dx.doi.org/10.1038/ja.2017.92 | DOI Listing |
Fungal Biol
October 2025
University of Tuscia, Department of Agriculture and Forest Sciences (DAFNE), Via San Camillo de Lellis SNC, Viterbo, Italy.
Fusarium Head Blight (FHB), caused by various Fusarium species, is a major threat to global cereal production. F. avenaceum is an important FHB pathogen producing enniatin mycotoxins.
View Article and Find Full Text PDFNat Commun
August 2025
Aix Marseille Univ, CNRS, Inserm, Institut Paoli-Calmettes, Centre de Recherche en Cancérologie de Marseille (CRCM), Marseille, France.
Histone deacetylases (HDACs) are epigenetic regulators frequently altered in cancer. Here we report that overexpression of HDAC1/2 occurs in Hepatocellular Carcinoma (HCC) patients, correlating with poor prognosis. We show that romidepsin, a class-I HDAC inhibitor, elicits a combinatorial perturbation of distinct molecular processes in HCC cells, altering lipid composition, mitotic spindle machinery, and levels of cell cycle/survival signals.
View Article and Find Full Text PDFJ Org Chem
September 2025
Research Center for Marine Microbes, Laboratory of Tropical Marine Bio-Resources and Ecology, Guangdong Key Laboratory of Marine Materia Medica, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, China.
Verlamelin A is a naturally occurring macrocyclic depsipeptide exhibiting high and broad-spectrum antifungal activity. The first unified total synthesis of verlamelin A and its (5)-verlamelin A (C5-epimer) is reported. This strategy involved homogeneous solution-phase synthesis of Fmoc-l-Val-O-(5/5)-tetradecanoic acid, solid-phase peptide synthesis of pentapeptide NH-d-allo-Thr-d-Ala-l-Pro-l-Gln-d-Tyr-OH, on-resin coupling of these two fragments to form a linear precursor , and off-resin cyclization followed by global deprotection to generate the final verlamelin A and (5)-verlamelin A in 6.
View Article and Find Full Text PDFACS Infect Dis
August 2025
Department of Medicinal Chemistry, Shandong Key Laboratory of Druggability Optimization and Evaluation for Lead Compounds, School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, Shandong 250012, China.
Increasingly, antimicrobial resistance has become a major concern for public health. The recently discovered cyclic depsipeptide, clovibactin, is a potential antibiotic candidate with potent activities against multidrug-resistant pathogens. It contains three d-amino acids, including a rare d-hydroxyasparagine residue.
View Article and Find Full Text PDFJ Am Chem Soc
September 2025
Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California San Diego, La Jolla, California 92093, United States.
Kahalalide F is a cyclic depsipeptide with notable anticancer properties, initially discovered from the green alga sp. and its molluscan predator . Recent studies have pinpointed a bacterial endosymbiont of the green alga, Endobryopsis kahalalidefaciens, as the true producer of kahalalide F.
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