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Oil and gas (O&G) production in the United States has increased in the last 15 years, and operations, which are trending toward large multiwell pads, release hazardous air pollutants. Health studies have relied on proximity to O&G wells as an exposure metric, typically using an inverse distance-weighting (IDW) approach. Because O&G emissions are dependent on multiple factors, a dynamic model is needed to describe the variability in air pollution emissions over space and time. We used information on Colorado O&G activities, production volumes, and air pollutant emission rates from two Colorado basins to create a spatiotemporal industrial activity model to develop an intensity-adjusted IDW well-count metric. The Spearman correlation coefficient between this metric and measured pollutant concentrations was 0.74. We applied our model to households in Greeley, Colorado, which is in the middle of the densely developed Denver-Julesburg basin. Our intensity-adjusted IDW increased the unadjusted IDW dynamic range by a factor of 19 and distinguishes high-intensity events, such as hydraulic fracturing and flowback, from lower-intensity events, such as production at single-well pads. As the frequency of multiwell pads increases, it will become increasingly important to characterize the range of intensities at O&G sites when conducting epidemiological studies.
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http://dx.doi.org/10.1021/acs.est.7b02084 | DOI Listing |
Biomed Eng Lett
September 2025
Department of Cardiovascular Ultrasound, The First Hospital of China Medical University, Shenyang, China.
Abstract: Hypertrophic cardiomyopathy (HCM) is a common hereditary heart disease and is the leading cause of sudden cardiac death in adolescents. Septal hypertrophy (SH) and apical hypertrophy (AH) are two common types. The former is characterized by abnormal septal myocardial thickening and the latter by left ventricular apical hypertrophy, both of which significantly increase the risk of heart failure, arrhythmias, and other serious complications.
View Article and Find Full Text PDFEnviron Res
September 2025
Department of Environmental Health, Harvard TH Chan School of Public Health, Boston, MA, USA; Department of Epidemiology, Harvard TH Chan School of Public Health, Boston, MA, USA.
Background: Fine particulate matter (PM) has been previously linked to cardiovascular diseases (CVDs). PM is a mixture of components, each of which has its own toxicity profile which are not yet well understood. This study explores the relationship between long-term exposure to PM components and hospital admissions with CVDs in the Medicare population.
View Article and Find Full Text PDFBiology (Basel)
August 2025
East China Sea Fisheries Research Institute, Chinese Academy of Fishery Sciences, Shanghai 200090, China.
Bigeye grunt () is a dominant fish species and mostly a major target species in both artisanal and industrial fisheries in the coastal waters of Sierra Leone. It was listed as near threatened in 2015 by the International Union for Conservation of Nature (IUCN) Red List. Although this species has been repeatedly assessed as overexploited by the Fishery Committee for the Eastern Central Atlantic (CECAF) in the majority of its range in the Eastern Central Atlantic, there have never been studies of stock assessment in the coastal waters of Sierra Leone.
View Article and Find Full Text PDFSci Robot
September 2025
Google DeepMind, London, UK.
Modern robotic manufacturing requires collision-free coordination of multiple robots to complete numerous tasks in shared, obstacle-rich workspaces. Although individual tasks may be simple in isolation, automated joint task allocation, scheduling, and motion planning under spatiotemporal constraints remain computationally intractable for classical methods at real-world scales. Existing multiarm systems deployed in industry rely on human intuition and experience to design feasible trajectories manually in a labor-intensive process.
View Article and Find Full Text PDFiScience
September 2025
State Key Laboratory of Pharmaceutical Biotechnology, The University of Hong Kong, Hong Kong, China.
Cancer progression is characterized by dysregulated G1/S phase transition mediated by CDK4/6-dependent Rb protein phosphorylation. Although CDK4/6 degraders show encouraging anti-tumor efficacy, it is highly desired to develop strategies to spatiotemporally control the release of active CDK4/6 degraders to further reduce adverse effects. In this study, we employ an optochemical strategy for CDK4/6 degradation by caging the CRBN ligand with a photoremovable protecting group.
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