Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
ARGONAUTE (AGO) proteins are eukaryotic RNA silencing effectors that interact with their binding partners via short peptide motifs known as AGO hooks. AGO hooks tend to cluster in one region of the protein to create an AGO-binding platform. In addition to the presence of AGO hooks, AGO-binding platforms are intrinsically disordered, contain tandem repeat arrays, and have weak sequence conservation even between close relatives. These characteristics make it difficult to identify and perform evolutionary analysis of these regions. Because of their weak sequence conservation, only a few AGO-binding platforms are characterized, and the evolution of these regions is only poorly understood. In this chapter we describe modules developed for computational identification and evolutionary analysis of AGO-binding platforms, with particular emphasis on understanding evolution of the tandem repeat arrays.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1007/978-1-4939-7165-7_19 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Return of genetic research results in 21,532 individuals with autism.
Genet Med
October 2024
Division of Genetics and Genomics, Department of Pediatrics, Boston Children's Hospital, Boston, MA; Department of Pediatrics, Harvard Medical School, Boston, MA. Electronic address:
Purpose: The aim of this study is to identify likely pathogenic (LP) and pathogenic (P) genetic results for autism that can be returned to participants in SPARK (SPARKforAutism.org): a large recontactable cohort of people with autism in the United States. We also describe the process to return these clinically confirmed genetic findings.
View Article and Find Full Text PDFOscillatory extraction behaviour suggests functional attributes of crows' hooked-stick tools.
Anim Cogn
June 2023
, Andelot en Montagne, France.
New Caledonian crows are the only nonhuman animals known to craft hooked-sticks for use in foraging. Since their first description over 25 years ago, researchers have been unable to provide a detailed account of how these complex tools function in natural probe sites. Using close-up video footage, we document how a New Caledonian crow operated a hooked-stick to extract a large tree weta from a chamber in a tree trunk.
View Article and Find Full Text PDFPhylogenetic position of the enigmatic genus and description of sp. nov. (Annelida: Spionidae) from Japan.
PeerJ
January 2023
Department of Biology, Center for Liberal Arts & Sciences, Iwate Medical University, Yahaba-cho, Shiwa-gun, Iwate, Japan.
Background: There are currently two species within the small enigmatic genus Mackie & Duff, 1986, which belongs to the - group in the family Spionidae Grube, 1850. The taxonomic relationship of the genus with other spionid or spioniform genera is currently not well understood due to its unusual morphological characteristics.
Methods: Here, we describe a new species, , based on materials collected from three localities in Japan: Hirota Bay (Iwate Prefecture), Ago Bay (Mie Prefecture), and Yakushima Island (Kagoshima Prefecture).
Adenosine, caffeine, and sleep-wake regulation: state of the science and perspectives.
J Sleep Res
August 2022
Institute of Pharmacology and Toxicology, University of Zürich, Zürich, Switzerland.
For hundreds of years, mankind has been influencing its sleep and waking state through the adenosinergic system. For ~100 years now, systematic research has been performed, first started by testing the effects of different dosages of caffeine on sleep and waking behaviour. About 70 years ago, adenosine itself entered the picture as a possible ligand of the receptors where caffeine hooks on as an antagonist to reduce sleepiness.
View Article and Find Full Text PDF