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Much of the undescribed biodiversity on Earth is microbial, often in mutualistic or pathogenic associations. Physically associated and coevolving life forms comprise a symbiome. We propose that systematics research can accelerate progress in science by introducing a new framework for phylogenetic analysis of symbiomes, here termed SYMPHY (symbiome phylogenetics).
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http://dx.doi.org/10.1016/j.tree.2017.05.002 | DOI Listing |
Aust Vet J
August 2025
School of Veterinary Medicine, College of Environmental and Life Sciences, Murdoch University, Murdoch, Western Australia, Australia.
Background: The emergence of Ehrlichia canis in northern Australia in 2020 has reshaped the landscape of tick-borne diseases in dogs, particularly in rural and remote communities where the brown dog tick (Rhipicephalus linnaei) is endemic. Despite the rapid spread of ehrlichiosis and reported impacts on dog health, its prevalence remains poorly understood. This study aims to provide baseline data on the epidemiology of E.
View Article and Find Full Text PDFExp Physiol
September 2025
Department of Biomedical Sciences, Ohio Musculoskeletal and Neurological Institute (OMNI), Heritage College of Osteopathic Medicine at Ohio University, Athens, Ohio, USA.
What do Charles Darwin, T.H. Huxley, August Krogh and Charles Sherrington have in common? Florence Buchanan - a name history has unjustly dimmed but never erased.
View Article and Find Full Text PDFFASEB J
March 2025
Department of Biology and Biotechnologies "Charles Darwin", Sapienza University of Rome, Rome, Italy.
SPP1+ macrophages, characterized by elevated expression of the osteopontin gene (secreted phosphoprotein 1, SPP1), have emerged as key players in various pathological contexts, including aging, chronic inflammatory diseases, and cancer. While frequently classified as a subclass of tumor-associated macrophages in oncological settings, their presence in noncancer conditions, such as aging-related disorders and muscular diseases, suggests a broader role beyond tumors. These macrophages share conserved traits, including fibrosis promotion, extracellular matrix remodeling, and immune modulation, often linked to poor clinical outcomes.
View Article and Find Full Text PDFJ Exp Clin Cancer Res
January 2025
Department of Biology and Biotechnologies "Charles Darwin", Sapienza University, 00185, Rome, Italy.
Background: Metabolic syndrome represents a pancreatic ductal adenocarcinoma (PDAC) risk factor. Metabolic alterations favor PDAC onset, which occurs early upon dysmetabolism. Pancreatic neoplastic lesions evolve within a dense desmoplastic stroma, consisting in abundant extracellular matrix settled by cancer associated fibroblasts (CAFs).
View Article and Find Full Text PDFSubcell Biochem
January 2025
Department of Biology and Biotechnologies C. Darwin, Sapienza University of Rome, Rome, Italy.
Epigenetic mechanisms are key processes that constantly reshape genome activity carrying out physiological responses to environmental stimuli. Such mechanisms regulate gene activity without modifying the DNA sequence, providing real-time adaptation to changing environmental conditions. Both favorable and unfavorable lifestyles have been shown to influence body and brain by means of epigenetics, leaving marks on the genome that can either be rapidly reversed or persist in time and even be transmitted trans-generationally.
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