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Background: Despite its wide implementation, there is a paucity of data supporting the effectiveness of regular alcohol urine screening (RAUS) in maintaining abstinence. This study aims at investigating if RAUS serves other purposes, what attitudes patients display towards it, and patients' technical knowledge about basic screening notions.
Method: We conducted a cross-sectional survey among adults with alcohol dependence, attending outpatient alcohol-dependence treatment. It aimed at investigating patients' attitudes and beliefs towards RAUS, and technical notions of alcohol urine screening. For attitude assessment, we adapted the Drug Attitude Inventory (DAI-10) to the field of alcohol urine screening. Internal consistency, test-retest reliability, and concurrent validity were evaluated for the adapted questionnaire.
Results: In all, 128 patients completed the questionnaire. Patients rated RAUS as high. The DAI-10 mean score was 7.2 (SD = 3.6). Internal consistency analysis revealed a Cronbach alpha of 0.718. Test-retest reliability evaluation yielded an intraclass correlation coefficient of 0.932. The score of a single Likert-type question about overall perceived value was 8.5 (SD = 2). Their correlation with mean DAI-10 score was of r = 0.254, with P = 0.009. Apart from relapse prevention, patients frequently reported other functions such as showing professionals and family members that they do not drink, or having a closer contact with professionals. A majority of patients believed alcohol use goes undetected after 48 hours from last ingestion.
Conclusion: Regular alcohol screening is highly valued by alcohol outpatients. It seems that apart from relapse prevention, other functions related to therapeutic alliance building, social desirability, and impression management also play a key role.
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http://dx.doi.org/10.1097/ADM.0000000000000315 | DOI Listing |
Metabolomics
September 2025
Department of Biochemistry, University of Oxford, South Parks Road, Oxford, OX1 3QU, UK.
Introduction: Knockout of the Fmo5 gene in mice led to a lean, slow-ageing phenotype characterised by the presence of 2,3-butanediol isomers in their urine and plasma. Oral treatment of wildtype mice with 2,3-butanediol led to a low cholesterol, low epididymal fat phenotype.
Objectives: Determine if significant, heterozygous coding variations in human FMO5 would give rise to similar clinical and metabolic phenotypes in humans, as in C57BL/6J mice with knockout of the Fmo5 gene and in particular, increased excretion of 2,3-butanediol.
J Anal Toxicol
September 2025
Department of Laboratory Medicine, Mayo Clinic Arizona, Phoenix, AZ, USA.
Background: Alcohol biomarkers including ethyl glucuronide (EtG) and phosphatidylethanol (PEth) are ordered frequently in clinical and forensic settings including solid organ transplantation. PEth provides a long detection window but can be insensitive to light drinking. In contrast, EtG and ethyl sulfate (EtS) can be elevated after light alcohol consumption and might complement PEth testing.
View Article and Find Full Text PDFTalanta
August 2025
Associate Laboratory i4HB - Institute for Health and Bioeconomy, University of Porto, Porto, Portugal; UCIBIO - Applied Molecular Biosciences Unit, Laboratory of Toxicology, Faculty of Pharmacy, University of Porto, Porto, Portugal. Electronic address:
Early detection of bladder cancer (BC) remains a major clinical challenge due to the limitations of current diagnostic methods, which are often invasive, expensive, or insufficiently sensitive, particularly for early-stage disease. Metabolomics approaches, when integrated with machine learning (ML) techniques, offer a powerful platform for identifying novel, non-invasive biomarkers. In this study, urinary volatile organic compounds (VOCs) were analysed from 87 BC patients and 90 age- and sex-matched cancer-free controls using headspace solid-phase microextraction coupled with gas chromatography-mass spectrometry (HS-SPME/GC-MS).
View Article and Find Full Text PDFAnal Chim Acta
October 2025
State Key Laboratory of Digital Medical Engineering, School of Biological Science and Medical Engineering, Southeast University, Nanjing, 210096, PR China. Electronic address:
Mimicking the structure of natural laccase, we designed and synthesized a Cu-clusterzyme with Cu atom as the catalytic center, histidine and cysteine as the recognition unit and auxiliary fluorescence unit, respectively (denoted as Cys-His-CuNCs). Cys-His-CuNCs integrate the dual properties of laccase-like catalysis and fluorescence-sensing, and can simultaneously catalyze and detect the neurotransmitter epinephrine (EP). Cys-His-CuNCs exhibit a 44-fold higher catalytic activity than laccase.
View Article and Find Full Text PDFReprod Toxicol
September 2025
State Key Laboratory of Reproductive Medicine and Offspring Health, Nanjing Medical University, Nanjing, Jiangsu 211166, China; Department of Maternal, Child and Adolescent Health, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, Jiangsu 211166, China; State Ke
Background/objectives: Phthalates are a group of ubiquitous environmental endocrine disruptors that can be detected in human body and exert adverse effects on reproductive health. We aimed to explore the correlation of phthalate exposure with polycystic ovary syndrome (PCOS).
Methods: We included 420 females who underwent assisted reproductive technology (ART) treatments between 2015 and 2018 in Jiangsu, China, comprising 94 PCOS cases and 326 controls.