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Background: Deaths from cardiovascular disease (CVD), including coronary heart disease (CHD) and stroke are expected to increase in Latin America. Moderate and regular alcohol consumption confers cardiovascular protection, while binge drinking increases risk. We estimated the effects of alcohol use on the number of annual CHD and stroke deaths and disability-adjusted life years (DALYs) in Argentina.
Methods: Alcohol use data were obtained from a nationally representative survey (EnPreCosp 2011), and etiological effect sizes from meta-analyses of epidemiological studies. Cause-specific mortality rates were from the vital registration system.
Results: There were 291,475 deaths in 2010 including 24,893 deaths from CHD and 15,717 from stroke. 62.7% of men and 38.7% of women reported drinking alcohol in the past year. All heavy drinkers (i.e. women who drank >20g/day and men who drank >40g/day of alcohol) met the definition of binge drinking and therefore did not benefit from cardioprotective effects. Alcohol drinking prevented 1,424 CHD deaths per year but caused 935 deaths from stroke (121 ischemic and 814 hemorrhagic), leading to 448 CVD deaths prevented (58.3% in men). Alcohol use was estimated to save 85,772 DALYs from CHD, but was responsible for 52,171 lost from stroke.
Conclusions: In Argentina, the cardioprotective effect of regular and moderate alcohol drinking is slightly larger than the harmful impact of binge drinking on CVD. However, considering global deleterious effects of alcohol in public health, policies to reduce binge drinking should be enforced, especially for young people. Studies are still needed to elucidate effects on cardiovascular health.
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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0173704 | PLOS |
Neuropsychopharmacology
September 2025
Bowles Center for Alcohol Studies, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Excessive alcohol use causes a great deal of harm and negative health outcomes. Corticotrophin releasing factor (CRF), a stress-related neuropeptide, has been implicated in binge ethanol intake and ethanol dependence in rodents. CRF containing neurons in the bed nucleus of the stria terminalis (BNST) can influence ethanol consumption.
View Article and Find Full Text PDFInt J Drug Policy
September 2025
Department of Geography and Rural Development, Kwame Nkrumah University of Science and Technology, KNUST, P. O. Box Up 1279 AK-447-9691, Kumasi, Ghana.
Despite rising concerns about alcohol use in artisanal mining, a focused investigation into its psychosocial drivers and mental health implications within sub-Saharan Africa's informal mining sector remains scarce. This study investigates the prevalence, motivations, and the association between alcohol use and mental health outcomes (depression, anxiety, and stress) among artisanal miners in Ghana. Using community based cross-sectional survey data from 664 miners, alcohol use was assessed using the Alcohol Use Disorders Identification Test, while symptoms of anxiety, stress, and depression were measured via the GAD-7, PSS, and PHQ-9 instruments.
View Article and Find Full Text PDFJ Neuroimmunol
September 2025
The University of Texas at Austin, College of Pharmacy, Division of Pharmacology & Toxicology, Austin, TX, 78712, United States of America. Electronic address:
Adolescents who consume alcohol show a high prevalence of binge drinking, which has been linked to brain damage and neuroimmune reactions that increase risk for developing an alcohol use disorder (AUD). Adolescent female drinking patterns have surpassed males, yet little is known about damaging effects of alcohol in females. Known sex differences in neuroimmune reactivity, specifically microglial reactivity, suggest that the female brain will differ from males.
View Article and Find Full Text PDFAlcohol Clin Exp Res (Hoboken)
September 2025
Alcohol Research Group, Public Health Institute, Emeryville, California, USA.
Background: Individuals who consume alcohol often use other drugs as well. Little is known about the clustering of heavy and binge drinking with the use of other substances (tobacco, cannabis, illicit drugs, and nonmedical prescription drugs). Overweight/obesity, highly prevalent in the United States (US) and an established health risk factor, may also cluster with them.
View Article and Find Full Text PDFCell Mol Gastroenterol Hepatol
September 2025
Department of Biological Sciences, The University of Texas at Dallas, Richardson, Texas. Electronic address:
Background & Aims: Binge drinking causes fat accumulation in the liver and is a known risk factor for more severe forms of alcohol-associated liver disease (ALD). Although adipocyte-released free fatty acids (FFA) have been shown to contribute to alcohol-induced liver damage, the signaling pathways that trigger lipolytic activity in adipose tissues following acute alcohol overconsumption is largely unknown. Notably, activation of sympathetic nerve-β3 adrenergic receptor (Adrb3) plays a central role in sustained adipocyte lipolysis.
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