Basigin rs8259 Polymorphism Confers Decreased Risk of Chronic Heart Failure in a Chinese Population.

Left ventricular remodeling is an essential risk factor contributing to the pathogenesis of chronic heart failure (CHF). Basigin (BSG) promotes cardiovascular inflammation and myocardial remodeling processes by induction of extracellular matrix metalloproteinases and inflammatory cytokines. rs8259 polymorphism was associated with BSG expression and risk of acute coronary syndrome. Therefore, we investigated whether rs8259 polymorphism contributes to risk and prognosis of CHF in Chinese patients. In total 922 adult patients with CHF and 1107 matched healthy controls were enrolled. rs8259 polymorphism was genotyped using PCR-restriction fragment length polymorphism. Whole blood mRNA expression data from Genotype-Tissue Expression project was accessed. Evaluation of follow-up data was performed in only 15.2% (140) of the patients with CHF. rs8259 TT genotype was associated with a decreased risk of CHF (OR = 0.83, 95% CI = 0.72-0.96, = 0.010), especially in patients with hypertension (OR = 0.80, 95% CI = 0.68-0.95, = 0.011) and coronary heart disease (OR = 0.81, 95% CI = 0.69-0.96, = 0.013) after adjustment for multiple cardiovascular risk factors. Rs8259 T allele was associated with decreased mRNA in whole blood from 338 healthy normal donors ( = 1.31 × 10). However, rs8259 polymorphism failed to exhibit an association with cardiovascular mortality ( = 0.283). rs8259 polymorphism may contribute to decreased risk of CHF in a Chinese Han population.