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http://dx.doi.org/10.1017/S1478951517000049 | DOI Listing |
Int J Biol Macromol
September 2025
Department of Computational Biology, Indraprastha Institute of Information Technology Delhi (IIIT-Delhi), Okhla Phase III, New Delhi, 110020, India; Infosys Centre for Artificial Intelligence, Indraprastha Institute of Information Technology Delhi (IIIT-Delhi), Okhla Phase III, New Delhi, 110020, In
Understanding the structural and functional diversity of toxin proteins is critical for elucidating macromolecular behavior, mechanistic variability, and structure-driven bioactivity. Traditional approaches have primarily focused on binary toxicity prediction, offering limited resolution into distinct modes of action of toxins. Here, we present MultiTox, an ensemble stacking framework for the classification of toxin proteins based on their molecular mode of action: neurotoxins, cytotoxins, hemotoxins, and enterotoxins.
View Article and Find Full Text PDFOncol Res
September 2025
Department of Urology, Fudan University Shanghai Cancer Center, Shanghai, 200032, China.
Studies have reported the special value of PANoptosis in cancer, but there is no study on the prognostic and therapeutic effects of PANoptosis in bladder cancer (BLCA). This study aimed to explore the role of PANoptosis in BLCA heterogeneity and its impact on clinical outcomes and immunotherapy response while establishing a robust prognostic model based on PANoptosis-related features. Gene expression profiles and clinical data were collected from public databases.
View Article and Find Full Text PDFPNAS Nexus
September 2025
Laboratoire Charles Coulomb (L2C), Université de Montpellier and CNRS (UMR 5221), Montpellier 34095, France.
Active-matter systems are inherently out-of-equilibrium and perform mechanical work by utilizing their internal energy sources. Breakdown of time-reversal symmetry (BTRS) is a hallmark of such dissipative nonequilibrium dynamics. We introduce a robust, experimentally accessible, noninvasive, quantitative measure of BTRS in terms of the Kullback-Leibler divergence in collision events, demonstrated in our novel artificial active matter, comprised of battery-powered spherical rolling robots whose energetics in different modes of motion can be measured with high precision.
View Article and Find Full Text PDFEvol Med Public Health
July 2025
Department of Anthropology, Department of Public Health, Wayne State University, Detroit, MI, USA.
Caesarean birth has multiple, interrelated, and often mutually reinforcing bio-social etiologies. Evolutionary consequences of caesarean are uncertain. The goal of this study is to determine if caesarean births are more likely within family lineages by connecting and comparing lifetime birth experience (caesarean, vaginal) of individual women and generations of their families.
View Article and Find Full Text PDFNeurol Clin Pract
October 2025
Department of Neurology, Division of Neurocritical Care and Emergency Neurology, Program in Trauma, University of Maryland, Baltimore, MD.
Background And Objectives: Guidelines for super-refractory status epilepticus (SRSE) evaluation, management, and prognostication are lacking. Characterization of practice patterns could identify trends and potential areas for future inquiry. We surveyed clinicians who manage SRSE to better understand practice approaches to SRSE evaluation, management, and prognostication.
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