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http://dx.doi.org/10.1093/ajh/hpw203 | DOI Listing |
Mol Biol Rep
September 2025
Chitkara College of Pharmacy, Chitkara University, Rajpura, 140401, Punjab, India.
Neuroinflammation, a vital protective response for tissue homeostasis, becomes a detrimental force when chronic and dysregulated, driving neurological disorders like Alzheimer's, Parkinson's, and Huntington's diseases. Potassium (K) channels maintain membrane potential and cellular excitability in neurons and glia within the intricate CNS signaling network. Neuronal injury or inflammation can disrupt K channel activity, leading to hyperexcitability and chronic pain.
View Article and Find Full Text PDFJ Vet Intern Med
September 2025
Department of Specialty Medicine, Midwestern University College of Veterinary Medicine, Glendale, Arizona, USA.
Background: Vitamin D modulates the immune response in many species, including dogs. To date, research investigating the immunological effects of vitamin D in dogs is limited to in vitro studies.
Objectives: Provide PO calcifediol supplementation to healthy dogs to evaluate its tolerability and assess its effect on leukocyte production of tumor necrosis factor (TNF)-α, interleukin (IL)-6, and IL-10.
Int J Cancer
September 2025
Department of Biochemistry and Molecular Biology, Faculty of Biology, National and Kapodistrian University of Athens, Athens, Greece.
Bladder cancer (BlCa) exhibits a highly heterogeneous molecular landscape and treatment response, underlining the pressing need for personalized prognosis. N6-methyladenosine (m6A) constitutes the most abundant RNA modification, modulates RNA biology/metabolism, and maintains cellular homeostasis, with its dysregulation involved in cancer initiation and progression. Herein, we evaluated the clinical value of METTL3 m6A methyltransferase, the main catalytic component of m6A methylation machinery, in improving BlCa patients' risk stratification and prognosis.
View Article and Find Full Text PDFEduc Psychol Meas
September 2025
Maastricht University, Maastricht, the Netherlands.
Measurement appropriateness concerns the question of whether the test or survey scale under consideration can provide a valid measure for a specific individual. An aberrant item response pattern would provide internal counterevidence against using the test/scale for this person, whereas a more typical item response pattern would imply a fit of the measure to the person. Traditional approaches, including the popular Lz person fit statistic, are hampered by their two-stage estimation procedure and the fact that the fit for the person is determined based on the model calibrated on data that include the misfitting persons.
View Article and Find Full Text PDFAnn Gastroenterol Surg
September 2025
We reviewed the current status and perspectives on salvage esophagectomy for initially unresectable locally advanced esophageal squamous cell carcinoma (ESCC) in the era of minimally invasive surgery and immunotherapy. Although the standard treatment for these patients is definitive chemoradiotherapy (CRT), the complete response rate to CRT alone remains unsatisfactory. Salvage esophagectomy, which is defined as surgery for residual or recurrent lesions after definitive CRT, is considered a curative treatment in clinical practice.
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