Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Objective: This study aimed at exploring the role of microRNA-21 (miR-21) in predicting brain metastases (BM) from non-small cell lung cancer (NSCLC).
Methods: A total of 132 NSCLC patients, including 68 patients with BM and 64 patients without BM, were included in the study. NSCLC cells were collected and assigned to the inhibitor (IN) group, the mock group, and the negative control (NC) group. The quantitative real-time polymerase chain reaction assay was used to detect the miR-21 expression. Cell proliferation, migration, invasion, and apoptosis were detected by colony-forming assay, MTT assay, transwell assay, and flow cytometry, respectively. Angiogenesis was measured by endothelial cell tube formation assay.
Results: The miR-21 expression was higher in NSCLC patients with BM than in those without BM. The miR-21 expression in the IN group was lower than that in the NC and mock groups. Compared with the NC and mock groups, the values of optical density (OD) and the colony-forming number decreased in the IN group. Compared with the NC and mock groups, cell invasion and migration abilities significantly reduced in the IN group. The IN group had higher apoptosis rate than the NC and mock groups. The tube length was shorter and the number of junction points was less in the IN group in comparison to the NC and mock groups.
Conclusion: miR-21 might be a potential biomarker for the development of BM in NSCLC patients and could promote the proliferation, migration, invasion, and angiogenesis of NSCLC cells.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5207466 | PMC |
| http://dx.doi.org/10.2147/OTT.S116619 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Neural interaction explainable AI predicts drug response across cancers.
NAR Cancer
September 2025
Institute of Pathology, Charité-Universitätsmedizin Berlin, 10117 Berlin, Germany.
Personalized treatment selection is crucial for cancer patients due to the high variability in drug response. While actionable mutations can increasingly inform treatment decisions, most therapies still rely on population-based approaches. Here, we introduce neural interaction explainable AI (NeurixAI), an explainable and highly scalable deep learning framework that models drug-gene interactions and identifies transcriptomic patterns linked with drug response.
View Article and Find Full Text PDFA novel technology for margin extension and local control in breast conservation surgery: Saline-coupled intraoperative radiofrequency ablation (SIRA).
Surg Oncol
September 2025
Department of Breast Surgery at Northwestern Medical Group, USA.
Importance: Breast-conserving therapy (BCT) results in reoperation in ∼20 % of cases due to positive margins, and a 7-13 % recurrence risk at 5 years persists despite negative margins and radiation. Enhancing margin treatment is critical to reducing local recurrence and improving survival.
Objective: To optimize and evaluate the performance of a Saline-coupled Intraoperative Radiofrequency Ablation (SIRA) device in producing uniform 1 cm ablations in lumpectomy cavities and compare it to prior-generation RFA technology in previous clinical studies.
Effects of taVNS on physiological responses and cognitive performance during a mental stressor.
Cogn Affect Behav Neurosci
September 2025
Department of Behavioral and Cognitive Sciences, University of Luxembourg, Belval, 2, avenue de l'Universite, L- 4365, Esch sur-Alzette, Luxembourg.
Transcutaneous auricular vagus nerve stimulation (taVNS) affects autonomic function and enhances cognitive performance by increasing vagal activation and central noradrenergic activity. Nevertheless, the impact of taVNS on acute mental stress remains largely unexplored. This study examined whether taVNS can mitigate the acute sympathetic stress response and improve cognitive performance during a socially evaluated version of the Paced Auditory Serial Addition Task (PASAT).
View Article and Find Full Text PDFBias toward progress-oriented leaders: People prefer progress- over maintenance-oriented leaders even when a maintenance orientation is required.
J Exp Psychol Gen
September 2025
University of Cologne, Department of Psychology.
We uncover a dissociation between leadership preferences (for progress, protection, or maintenance-oriented leaders) and situational requirements (to make progress, protect, or maintain). Despite maintenance being crucial for sustaining groups' ongoing activity, we find a bias favoring progress-oriented leaders across contexts. In six preregistered experiments (Ntotal = 3,324), participants consistently preferred progress-oriented leaders even when they recognized maintenance as the primary situational need.
View Article and Find Full Text PDFHow authority affects social evaluations of negotiation words.
Cogn Res Princ Implic
September 2025
Department of Psychology, University of California, 1156 High St, Santa Cruz, CA, 95064, USA.
Understanding how authority affects social evaluation of written communication is crucial for understanding how online communication technologies can be effectively deployed. We examined how negotiation words affected perceived ratings of knowledgeableness, professionalism, politeness, and friendliness across three levels of authority (professor, teaching assistant, student) while asking and answering questions in a mock online forum. The greatest distinction across groups was in professionalism.
View Article and Find Full Text PDF