98%
921
2 minutes
20
Due to their ease of fabrication, facile use and low cost, ice valves have great potential for use in microfluidic platforms. For this to be possible, a rapid response speed is key and hence there is still much scope for improvement in current ice valve technology. Therefore, in this study, an ice valve with enhanced thermal conductivity and a movable refrigeration source has been developed. An embedded aluminium cylinder is used to dramatically enhance the heat conduction performance of the microfluidic platform and a movable thermoelectric unit eliminates the thermal inertia, resulting in a faster cooling process. The proposed ice valve achieves very short closing times (0.37 s at 10 μL/min) and also operates at high flow rates (1150 μL/min). Furthermore, the response time of the valve decreased by a factor of 8 when compared to current state of the art technology.
Download full-text PDF |
Source |
---|---|
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5234026 | PMC |
http://dx.doi.org/10.1038/srep40570 | DOI Listing |
J Am Coll Cardiol
August 2025
Division of Cardiovascular Disease, New York-Presbyterian/Columbia University Irving Medical Center, New York, New York, USA.
Background: Catheter-based percutaneous mechanical aspiration (PMA) is an emerging acute intervention for debulking infective vegetations in right-sided infective endocarditis (RSIE); however, its outcomes and safety remain undefined.
Objectives: The authors sought to assess early clinical outcomes and safety of PMA in patients with RSIE.
Methods: The CLEAR-IE (Cardiac Lesion Extraction and Aspiration Registry for Infective Endocarditis) is a large multicenter retrospective registry of consecutive patients with RSIE who have undergone PMA.
Int J Comput Assist Radiol Surg
August 2025
Biomedical Engineering, University of Technology Eindhoven, Groene Loper 3, 5612 AE, Eindhoven, The Netherlands.
Purpose: Valvular heart disease affects 2.5% of the general population and 10% of people aged over 75, with many patients untreated due to high surgical risks. Transcatheter valve therapies offer a safer, less invasive alternative but rely on ultrasound and X-ray image guidance.
View Article and Find Full Text PDFQuant Imaging Med Surg
August 2025
Department of Cardiology, The Affiliated Taizhou People's Hospital of Nanjing Medical University, Taizhou, China.
Background: Mitral regurgitation (MR) is the most common valvular heart disease in the general population. Establishing a reproducible and stable MR model is crucial for exploring the pathogenesis and treatment strategies of MR. This study optimized the entire modeling process based on the transcatheter method, aiming to provide a more reliable and stable strategy for constructing large animal models of MR.
View Article and Find Full Text PDFWe report a case of transcatheter paravalvular leak (PVL) closure assisted by three-dimensional (3D) printing and intracardiac echocardiography (ICE) in a patient with complex valvular history. A 70-year-old male manifested acute exacerbation of dyspnea, accompanied by orthopnea and nocturnal paroxysmal respiratory distress. Echocardiographic evaluation revealed severe aortic PVL.
View Article and Find Full Text PDFRev Cardiovasc Med
June 2025
Department of Cardiology, General Hospital Paphos, State Health Services Organization, 8026 Paphos, Cyprus.
Transcatheter aortic valve implantation (TAVI) is a minimally invasive procedure to treat severe aortic stenosis in select patients. Patients who have undergone TAVI are at high risk of infective endocarditis (IE), especially during the first year post-operation. Early diagnosis of IE is essential to initiate targeted antibiotic therapy and/or surgical intervention.
View Article and Find Full Text PDF