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Article Abstract
We developed a novel Pb-sensor based on a microcantilever that was modified with a specific Pb-dependent DNAzyme molecule. This microcantilever sensor could detect Pb sensitively and selectively in an aqueous solution. Upon complexation with Pb, the DNAzyme duplex unwinded and formed a G-quadruplex conformation, which led to an increase of repulsion between the DNAzyme molecules and a subsequent bending of the microcantilever. This microcantilever sensor could be regenerated, flowing through a strong Pb chelator, 1,4,7,10-tetraazacyclododecane- 1,4,7,10-tetraacetic acid. The detection limit of the microcantilever sensor for Pb ions is as low as 10 M. The microcantilever sensor also exhibited a high selectivity to Pb over other metal ions such as Mg, Fe, Zn, Ca, and Cd.
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| http://dx.doi.org/10.2116/analsci.32.1065 | DOI Listing |
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