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The normal function of the urinary bladder is to store and expel urine in a coordinated, controlled fashion, the activity of which is regulated by the central and peripheral nervous systems. Neurogenic bladder is a term applied to a malfunctioning urinary bladder due to neurologic dysfunction or insult emanating from internal or external trauma, disease, or injury. This report describes a case of neurogenic bladder following laminectomy procedure and long-standing diabetes mellitus with neuropathy treated with autologous cellular therapy. The differentiation potential and paracrine effects of mesenchymal stem cells on bladder function have been highlighted.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5021461 | PMC |
http://dx.doi.org/10.1155/2016/2539320 | DOI Listing |
Adv Healthc Mater
September 2025
Department of Biomedical Engineering, University of Houston, Houston, TX, 77204, USA.
Neurogenic bladder and lower urinary tract (LUT) dysfunctions encompass a wide variety of urinary disorders resulting from nervous system impairments. Unfortunately, conventional treatments are still limited and can have significant complication rates, especially when stent implantations or other surgical procedures are involved. Therefore, there is a critical need to develop novel therapeutic strategies and pharmacological approaches to address these challenging urological conditions.
View Article and Find Full Text PDFFr J Urol
September 2025
Houston Methodist Hospital, Department of Urology, Houston, Texas, USA.
Zhonghua Nan Ke Xue
July 2025
Department of Neurosurgery, Liaocheng People's Hospital, Liaocheng, Shandong 252000, China.
Urinary dysfunction caused by central nervous system or peripheral nerve disease represents a significant global medical and social problem. Neurologic abnormalities, including traumatic brain injury (TBI), stroke, Alzheimer's disease, and Parkinson's disease, have been identified as potential risk factors for neurogenic urinary tract dysfunction. The relationship between TBI and neurogenic lower urinary tract dysfunction (NLUTD) will be introduced in this article, with the mechanisms, clinical manifestations, diagnostic methods, and treatment strategies of NLUTD after TBI being evaluated as well, which provides a reference for the diagnosis and treatment.
View Article and Find Full Text PDFCureus
August 2025
General Medicine, Universidad de Ciencias Médicas (UCIMED), San José, CRI.
Many patients with injuries to their central nervous system, especially those who have had a stroke or a spinal cord injury, have neurogenic voiding dysfunction. It happens when patients can't control their bladder voluntarily, which can make them feel urgency, experience leaks, or have trouble emptying their bladder. If not treated right away, it can cause infections, damage to the bladder, or even kidney problems over time.
View Article and Find Full Text PDFBiology (Basel)
July 2025
Institute of Molecular Regenerative Medicine, Paracelsus Medical University, 5020 Salzburg, Austria.
Spinal cord injury (SCI) frequently leads to neurogenic lower urinary tract dysfunction, for which appropriate bladder management is essential. While clinical care relies on continuous low-pressure drainage in the acute phase, rat models commonly use twice-daily manual bladder expression-a method known to generate high intravesical pressures and retention. This study evaluated the impact of this standard practice on bladder tissue remodeling by comparing it to continuous drainage via high vesicostomy in a rat SCI model.
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