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http://dx.doi.org/10.5698/1535-7511-16.4.254 | DOI Listing |
Epilepsy Behav
July 2025
Iranian Center of Neurological Research, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran; Medical Colleges, Shiraz University of Medical Sciences, Shiraz, Iran.
Background: Childhood epilepsy syndromes (CES) are a group of epilepsy disorders with significant variability in prognosis, treatment, and underlying etiology. This systematic review aims to shed light on the role of nuclear brain imaging in diagnosis, pretreatment assessment, and understanding pathophysiology.
Methodology: A comprehensive search of PubMed, Embase, Scopus, and Web of Science was conducted to identify studies evaluating positron emission tomography (PET) and single-photon emission computed tomography (SPECT) in CES.
Neuropsychiatr Dis Treat
June 2025
Laboratory of Neuropsychophysiology, Faculty of Psychology and Educational Sciences, University of Porto, Porto, Portugal.
Purpose: Benign rolandic epilepsy or benign epilepsy in childhood with centrotemporal spikes (BECTS) and developmental dyslexia (DD) are two of the most studied disorders in childhood. Despite decades of research, the neurophysiological mechanisms underpinning these disorders are largely unknown. Here, we use auditory event-related potentials (AERPs) to shed light on these issues, since several authors have reported the existence of language and learning impairments.
View Article and Find Full Text PDFJ Clin Neurophysiol
May 2025
Department of Pediatrics, Division of Neurology, BC Children's Hospital, Faculty of Medicine, University of British Columbia Vancouver, BC, Canada.
Purpose: Rolandic epileptiform discharges with tangential dipole (T-dipole) configurations are associated with favorable prognosis. Whether the same is true for T-dipole epileptiform discharges in other brain regions is less established and is the objective of this study.
Methods: Over 20 years, patients with epileptiform discharges were identified as follows: frontal (F = 176), temporal (T = 196), central (C = 201), parietal (P = 120), and occipital (O = 205).
J Neuroimmunol
July 2025
Shanghai Jiaotong Universtiy school of Medicine xinhua hospital, Department of Pediatric Neurology, People's Republic of China. Electronic address:
Introduction: Benign Epilepsy with Centrotemporal Spikes (BECTS) is the most common form of focal epilepsy in pediatric patients. In clinical practice, immune dysregulation and neuroinflammation have been observed in a subset of patients with BECTS harboring latent Herpesviridae infections, including the Epstein-Barr Virus (EBV) and Human Cytomegalovirus (CMV). Therefore, the present study aimed to explore the correlation between clinical characteristics and immune dysregulation in autoimmunity-associated BECTS and latent viral or Mycoplasma infections.
View Article and Find Full Text PDFBrain Stimul
April 2025
Department of Neurology & Neurological Sciences, Stanford University, Stanford, CA, USA. Electronic address:
Objective: Self-limited epilepsy with centrotemporal spikes (SeLECTS) is a common pediatric syndrome in which interictal epileptiform discharges (IEDs) emerge from the motor cortex and children often develop language deficits. IEDs may induce these language deficits by pathologically enhancing brain connectivity. Using a sham-controlled design, we test the impact of inhibitory low-frequency repetitive transcranial magnetic stimulation (rTMS) on connectivity and IEDs in SeLECTS.
View Article and Find Full Text PDF