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Objective: To estimate direct medical costs of diarrheal hospitalization of children <5 years admitted in pediatric intensive care unit (PICU) or high dependency unit (HDU).
Methods: Analysis of medical records and hospital bills of 84 children during two time frames, 2005-08 and 2012-14.
Results: Direct medical costs in PICU increased from INR 17,941 to INR 50,663 per child for rotavirus diarrhea and INR 11,614 to INR 27,106 for non-rotavirus diarrhea, and in HDU from approximately INR 5,800 to INR 10,500 per child for all-cause diarrhea between the two time frames.
Conclusions: Costs of PICU and HDU care are high and should be included in cost-effectiveness analysis of vaccination.
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http://dx.doi.org/10.1007/s13312-016-0902-4 | DOI Listing |
BMC Med Inform Decis Mak
September 2025
Emergency Department, Helios Spital, Überlingen, Germany.
Background: The increasing amount of data routinely collected on ICUs poses a challenge for clinicians which is aggravated with data-heavy therapies like Continuous Kidney Replacement Therapy (CKRT). We developed the CKRT Supporting Software Prototype (CKRT-SSP), a clinical decision support system for use before, during and after CKRT. The aim of this user experience (UX) study was to prospectively evaluate CKRT-SSP in terms of usability, user experience, and workload in a simulated ICU setting.
View Article and Find Full Text PDFStem Cell Rev Rep
September 2025
Department of Medical Genetics and Prenatal Diagnostics, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
The emergence of organoid models has significantly bridged the gap between traditional cell cultures/animal models and authentic human disease states, particularly for genetic disorders, where their inherent genetic fidelity enables more biologically relevant research directions and enhances translational validity. This review systematically analyzes established organoid models of genetic diseases across organs (e.g.
View Article and Find Full Text PDFJ Neural Transm (Vienna)
September 2025
Sárospatak College, Sztárai Institute, University of Tokaj, Eötvöst str. 7, Sárospatak, 3944, Hungary.
Generalized Anxiety Disorder (GAD) is characterized by excessive worry and physical symptoms of prolonged anxiety. Patients with subclinical GAD-states (sub-GAD) do not fulfill the diagnostic criteria of GAD, but they often show a disease burden similar to GAD, and the subclinical state may turn into a full syndrome. Neuroinflammation may contribute to changes in brain structures in sub-GAD, but direct evidence remains lacking.
View Article and Find Full Text PDFJ Cancer Res Clin Oncol
September 2025
Division of Gastroenterology, Department of Medicine, Asahikawa Medical University, Asahikawa, Japan.
Purpose: Next-generation sequencing (NGS) has revolutionized cancer treatment by enabling comprehensive cancer genomic profiling (CGP) to guide genotype-directed therapies. While several prospective trials have demonstrated varying outcomes with CGP in patients with advanced solid tumors, its clinical utility in colorectal cancer (CRC) remains to be evaluated.
Methods: We conducted a prospective observational study of CGP in our hospital between September 2019 and March 2024.
Sports Med
September 2025
Aspetar Orthopaedic and Sports Medicine Hospital, FIFA Medical Centre of Excellence, Doha, Qatar.
Sports injury surveillance programs have been vital in advancing the understanding of injury epidemiology across various athlete populations. Surveillance-based epidemiological measures of injury occurrence are ubiquitous in the sports medicine literature, and the injury rate is one such commonly used measure. Traditional approaches to calculating injury rates have predominantly relied on frequentist methods, which, while informative, have limitations in addressing certain practical questions.
View Article and Find Full Text PDF