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A 58-year-old Japanese woman came to our institution because of leg edema and abdominal distention. She had developed acute pancreatitis 5 times in the past 3 years. Dilation of the bile duct and main pancreatic duct without obstruction was observed on computed tomography and magnetic resonance cholangiopancreatography. The presence of Strongyloides stercoralis was highly suspected from the biopsy sample from the duodenal papilla. Polymerase chain reaction amplification and sequencing of small subunit rDNA from paraffin-embedded specimens identified the worm as S. stercoralis. All of the symptoms were considered to be associated with S. stercoralis infection. Therefore, the patient was treated with oral administration of ivermectin. Subsequently, symptoms and laboratory data improved. There has been no recurrence of the symptoms to date.
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http://dx.doi.org/10.2169/internalmedicine.55.4354 | DOI Listing |
Travel Med Infect Dis
September 2025
Health Research Institute of Asturias, Oviedo, Spain; Infectious Diseases Unit. Hospital Universitario Central de Asturias; Medicine Department, University of Oviedo, Oviedo, Spain. Electronic address:
Background: Autochthonous strongyloidiasis in Spain has traditionally been considered a recognized but underdiagnosed condition, primarily affecting individuals in agricultural environments along the Mediterranean coast. We describe the first series of autochthonous strongyloidiasis cases diagnosed in Asturias, a region in northern Spain with no previously documented endemic transmission.
Methods: This is a retrospective review of all diagnosed cases of autochthonous strongyloidiasis at the Central University Hospital of Asturias, from 2016 to 2024.
Trop Doct
August 2025
Professor, Department of Microbiology, Mata Gujri Memorial Medical College and L.S.K. Hospital, Kishanganj, Bihar, India.
, a soil-transmitted intestinal nematode is often undiagnosed owing to its non-specific clinical manifestations, laboratory findings and radiological features. Corticosteroids, HIV and Human T-cell lymphotrophic virus type-1 are some of the many immunocompromised conditions where strongyloidiasis infection might lead to a hyper-infection syndrome of disseminated strongyloidiasis. Albendazole, ivermectin and, recently, moxidectin are anti-helminthic drugs with excellent activity against this neglected tropical parasite.
View Article and Find Full Text PDFAm J Trop Med Hyg
August 2025
Department of Epidemiology and Biostatistics, Arnold School of Public Health, University of South Carolina, Columbia, South Carolina.
Strongyloides stercoralis, a soil-transmitted helminth, was historically known to persist throughout the southeastern United States, but data regarding current prevalence are lacking. This project aimed to evaluate potential seroprevalence and epidemiologic risk factors for Strongyloides infections among South Carolina (SC) residents. First, a cross-sectional serosurvey was conducted on banked serum samples, and seroprevalence status was compared with associated health questionnaires.
View Article and Find Full Text PDFIDCases
August 2025
Division of Geographic Medicine and Infectious Diseases, Tufts Medical Center, Boston, MA, USA.
can complete its entire life cycle within the human host, allowing infections to persist for years. While it may cause chronic, often asymptomatic infection in immunocompetent individuals, it can lead to life-threatening hyperinfection syndrome or disseminated disease in those who are immunocompromised. We report a case of hyperinfection syndrome in a heart transplant recipient who had tested negative on conventional serologic screening as part of his pretransplant workup three years prior to transplantation.
View Article and Find Full Text PDFTrop Med Int Health
August 2025
Laboratory of Immunobiology and Control of Parasites, Department of Parasitology, Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
Leprosy presents a broad clinical spectrum influenced by the host's immune response, and co-infections may further modulate disease progression. This study evaluated clinically diagnosed leprosy patients (n = 251) from Sergipe and Minas Gerais, Brazil, along with healthy controls (n = 43), soil-transmitted helminths-positive controls (n = 15), and household contacts (n = 176). Enzyme-linked immunosorbent assays were performed using predicted B-cell epitopes from immunogenic proteins of Ascaris sp.
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