Identification of a novel transcriptome signature for predicting the response to anti-TNF-α treatment in patients with rheumatoid arthritis.

Objectives: This study aims to identify and validate a transcriptomic signature capable of predicting the response to tumour necrosis factor inhibitors (TNFi) therapy in patients with rheumatoid arthritis (RA) before treatment initiation.

Methods: We performed a retrospective transcriptomic analysis using 2 public datasets, RNA-seq data from peripheral blood mononuclear cells (GSE138746) and microarray data from whole blood (GSE33377), to define a small-scale gene signature predictive of the response to TNFi treatment. Three external validations were then conducted, resulting in a total of 279 individuals, 169 responders, and 110 nonresponders.

First evidence of Significant Autochthonous Transmission of Strongyloidiasis in Northern Spain: A Retrospective Study from Asturias, Spain.

Background: Autochthonous strongyloidiasis in Spain has traditionally been considered a recognized but underdiagnosed condition, primarily affecting individuals in agricultural environments along the Mediterranean coast. We describe the first series of autochthonous strongyloidiasis cases diagnosed in Asturias, a region in northern Spain with no previously documented endemic transmission.

Methods: This is a retrospective review of all diagnosed cases of autochthonous strongyloidiasis at the Central University Hospital of Asturias, from 2016 to 2024.

Functional trade-offs and ecological correlates of seed oil traits in alpine ecosystems.

Seed oil content is a crucial energy reserve in angiosperms, with effects on biological functions and plant fitness, playing an important role in seed protection from environmental conditions. However, the eco-evolutionary role of seed oil traits in natural ecosystems is largely unexplored. We studied functional trade-offs and ecological drivers of seed oil traits in 47 species of an alpine flora.

Exercise- and diet-induced glycogen depletion impairs performance during one-legged constant-load, high-intensity exercise in humans.

Introduction: The effect of muscle glycogen stores on performance during intense short-duration exercises in humans is unclear. We hypothesized that low initial muscle glycogen levels would impair constant-load intense one-legged knee extensor exercise lasting approximately 5 min and human muscle contractile function, as determined by maximal voluntary contraction (MVC), electrically induced single-twitch maximal force, rate of force development (RFD), and rate of relaxation. Furthermore, alter phosphorylation of the Na/K-ATPase (NKA) regulatory proteins AMPK and FXYD1 indicating attenuated NKA activity.

Validity of a brief egocentric social network assessment in adults with alcohol use disorder: Direct comparison of 5-alter and 20-alter versions.

Social network analysis offers a high-resolution framework for understanding social influences on alcohol use, but full-length assessments confer significant burden, giving rise to brief measures. However, few studies have empirically compared brief and full-length assessments. To address this, the present study examined the internal and external validity of both brief and full egocentric social network assessments and their ability to capture weak social ties.

Early-life cognitive effects of prebiotics and probiotics: A cross-species systematic review.

This systematic review evaluated the effects of prebiotic and probiotic interventions on early-life cognitive development in animal models and humans. Following PRISMA 2020 guidelines, 39 studies published between 2015 and 2025 were included from PubMed, Scopus, and Web of Science. In rodents, probiotics -mainly Lactobacillus and Bifidobacterium strains- consistently improved spatial learning, working memory, and cognitive flexibility, particularly under conditions of early-life stress and neuroinflammation.

Physical foundations for trustworthy medical imaging: A survey for artificial intelligence researchers.

Artificial intelligence in medical imaging has grown rapidly in the past decade, driven by advances in deep learning and widespread access to computing resources. Applications cover diverse imaging modalities, including those based on electromagnetic radiation (e.g.

Targeted Screening Strategies for Head and Neck Cancer: A Global Review of Evidence, Technologies, and Cost-Effectiveness.

Head and neck cancer (HNC) is the seventh most common cancer worldwide, with rising incidence particularly in oropharyngeal cancer subsites. Despite well-known risk factors, such as tobacco and alcohol consumption as well as human papillomavirus (HPV) infection, most HNCs are diagnosed at an advanced stage, resulting in poor prognosis. Early detection and screening are critical, especially in high-risk populations.

Cutaneous Cancer Trends in Spain: An Emerging Epidemic with Shifting Tumor Types.

: The incidence of both non-melanoma and melanoma skin cancers has increased significantly in recent years. Understanding their epidemiology is essential for implementing effective community prevention strategies and optimizing healthcare resource planning. This study aimed to (1) quantify the number of skin tumors diagnosed at the Central University Hospital of Asturias (HUCA) from 2014 to 2023; (2) describe temporal trends in the incidence of basal cell carcinoma (BCC), squamous cell carcinoma (SCC), and melanoma; and (3) analyze the clinical and histopathological features of melanoma and estimate age-standardized incidence rates.

Effects of an mHealth Occupational Therapy Intervention on Functional Performance: A Pilot Study.

Unlabelled: Neurodevelopmental disorders are one of the most prevalent conditions today, and among the limitations in activity and restrictions in the participation of children and their families, we find intervention in activities of daily living; therefore, research focused on outcome measurement is one of the most active lines, and after COVID-19, telerehabilitation has garnered special interest.

Background/objectives: The study objective was to evaluate the effectiveness of a mobile health (mHealth) application in improving the performance of activities of daily living in children with neurodevelopmental disorders.

Methods: The study employed a quasi-experimental design with a control group, using a fully remote mHealth-based intervention.

Analysis of Determinant Factors and Mechanisms in Early Childhood Care Services: A Qualitative Study in the Asturian Context (Spain).

Diverse realities challenge the management capacity of public and private systems to ensure equitable quality and efficient access to resources, in line with the 2030 Agenda and the Sustainable Development Goals, which aim to close gaps in essential services and ensure quality of life. The reality in Spain, and more specifically in the Principality of Asturias, is that most resources are concentrated in urban areas rather than rural ones, partly due to the region's geography. : This study aimed to explore the perspectives of various stakeholders on the early childhood care system in the Principality of Asturias (Spain), with the purpose of analyzing the mechanisms and determinants involved in its functioning and identifying opportunities for improvement.

T-TEER for Tricuspid Valve Regurgitation: A Sex-Based Real-World Analysis from the TRI-SPA Registry.

Background: Impact of sex-related differences on clinical outcomes after tricuspid transcatheter edge-to-edge repair (T-TEER) for severe tricuspid regurgitation (TR) remains underexplored.

Methods: This sub-analysis of the Transcatheter Tricuspid Valve Repair in Spain (Tri-SPA) registry includes patients who underwent T-TEER for severe TR between June 2020 and May 2023 in Spain. Outcomes were compared by sex.

Metabarcoding Reveals Diversity of Potentially Toxic Algae in Papeete Port (Tahiti).

Harmful algae are transported in various compartments of maritime vessels, making ports with heavy maritime traffic potential hotspots for their introduction and spread. In this study, we investigate the port of Papeete (Tahiti, French Polynesia), a key hub for numerous South Pacific shipping routes. Using metabarcoding on DNA extracted from water samples (environmental DNA, eDNA) we identified 21 species of harmful algae comprising to Bacillariophyceae (4), Dinophyceae (14), and Haptophyta (3 species).

Nurse Perspectives on Prone Positioning for ARDS Patient in the ICU: A Qualitative Phenomenological Study of Facilitator and Barrier.

Introduction: Prone positioning is an established therapeutic intervention for acute respiratory distress syndrome (ARDS) patients. However, its utilization in ARDS treatment remains low, despite recommendations and evidence of its benefits.

Objective: This study aims to explore the phenomenon of performing prone position for ARDS patients in the intensive care unit (ICU), especially from the nurses' perspective of the facilitators and the barrier.

Validation and Administration of the Spanish Questionnaire 'Humanisation of Pediatric Care in Pain Management with a Non-Pharmacological Approach (HUPEDCARE-Q)'.

: The pain associated with invasive procedures is one of the most common experiences in the pediatric population. Its management remains insufficient due to gaps in healthcare training and knowledge. The aim of this study was to analyze the attitudes, beliefs, care practices, and training of healthcare professionals in relation to pediatric pain, through the development and application of the questionnaire 'Humanisation of Pediatric Care in Pain Management with a Non-Pharmacological Approach (HUPEDCARE-Q)'.

Fumonisin B Determination in Maize Products from Belize Using an Immunosensor Based on Screen-Printed Carbon Electrodes.

A competitive electrochemical immunosensor, using screen-printed carbon electrodes (SPCEs), was developed for the determination of total fumonisins (sum of FB1, FB2 and FB3) extracted with a simple solvent extraction and dilution method, without clean up, from maize flour and maize tortillas. The optimized biosensor has a linear range of 0.25 to 50 µg/L with 3% and 2% reproducibility for FB1 and (FB1 + FB2), respectively, and a linear range of 0.

Roadmap for Photonics with 2D Materials.

Triggered by advances in atomic-layer exfoliation and growth techniques, along with the identification of a wide range of extraordinary physical properties in self-standing films consisting of one or a few atomic layers, two-dimensional (2D) materials such as graphene, transition metal dichalcogenides (TMDs), and other van der Waals (vdW) crystals now constitute a broad research field expanding in multiple directions through the combination of layer stacking and twisting, nanofabrication, surface-science methods, and integration into nanostructured environments. Photonics encompasses a multidisciplinary subset of those directions, where 2D materials contribute remarkable nonlinearities, long-lived and ultraconfined polaritons, strong excitons, topological and chiral effects, susceptibility to external stimuli, accessibility, robustness, and a completely new range of photonic materials based on layer stacking, gating, and the formation of moiré patterns. These properties are being leveraged to develop applications in electro-optical modulation, light emission and detection, imaging and metasurfaces, integrated optics, sensing, and quantum physics across a broad spectral range extending from the far-infrared to the ultraviolet, as well as enabling hybridization with spin and momentum textures of electronic band structures and magnetic degrees of freedom.

Controlled Crystallization of Nanocrystalline Apatite via Vapor Diffusion on Bacterial Cellulose Membranes Obtained from Mango Waste.

Hybrid bacterial cellulose (BC)-calcium phosphate apatite (Ap) composite was successfully synthesized via the sitting drop vapor diffusion crystallization method. The BC matrix was produced using the bacterial strain sp. SU12 cultured in a medium derived from mango juice waste, underscoring a sustainable strategy for biopolymer production.

Effectiveness of a Flossing Protocol and Manual Therapy in Improving the Clinical and Functional Status of Subjects with Recurrent Ankle Sprains; A Double-Blind Randomized Clinical Trial.

: Recurrent ankle sprains can lead to chronic ankle instability. The flossing technique aims to modify the function and characteristics of fascial tissue. The objective was to evaluate the effectiveness of flossing and sliding techniques in improving subjects with previous ankle sprains.

Age-dependent effect of environmental enrichment on the neural 3D chromatin interactome.

Aging is a multifactorial biological process resulting in physiological and cellular decline. However, our understanding of age-related changes in 3D genome organization and the effect of external interventions on this process remains limited. Here, we describe alterations in the landscape of the 3D chromatin interactome upon aging, utilizing the low-input promoter capture Hi-C (liCHi-C) technique with mouse hippocampal neurons.

Psychometric properties of the Dating Violence Questionnaire for Victimization and Perpetration (DVQ-VP) in Ecuadorian population.

Objective: The aim of this study was to evaluate the psychometric properties of the Dating Violence Questionnaire for Victimization and Perpetration (DVQ-VP) in a sample of the Ecuadorian population.

Methods: The study included 819 participants (47% men and 53% women), consisting of Ecuadorian adolescents and university students. An instrumental design was employed for the linguistic adaptation, reliability, and convergent (AVE), discriminant (HTMT), and structural (CFI, TLI, and RMSEA) validation of the DVQ-VP.

Treatment-resistant depression and intranasal esketamine: Spanish consensus on theoretical aspects.

Introduction: Depression is a highly prevalent disease that severely impacts the life of patients. Inadequate response to at least two antidepressants despite adequacy of treatment and adherence is known as treatment-resistant depression (TRD), which entails a higher social and economic burden than non-resistant major depression. The lack of consensus on the definition of TRD and other aspects complicates management of the disease.

Photocatalytic Activity of Ionic Carbon Nitrides is Governed by Cation-Modulated Dark Exciton Dynamics.

Ionic polymeric carbon nitrides, poly(heptazine imides) (PHIs), have emerged as promising photocatalysts, yet the relationship between their structure, exciton dynamics, and activity has remained elusive so far. Here, a direct link is established between photocatalytic activity, spectroscopic properties, and theoretical analysis of structural effects on exciton behavior in water-soluble PHIs with different cations. Using steady-state and time-resolved emission spectroscopy alongside ultrafast transient absorption spectroscopy performed in the absence and presence of hole and electron quenchers, two distinct excitonic relaxation pathways are uncovered: sub-100 ps decay dominated by exciton recombination and shallow-trap states, and sub-ns dynamics associated with deep-trap assisted recombination.

A novel data augmentation technique based on wheezing physiological modeling applied to asthma severity management in respiratory sounds.

Wheezing sounds are critical biomarkers for diagnosing respiratory disorders, including asthma. Recent advancements still depend on the availability of high-quality training datasets. The creation of public databases containing a diverse array of wheezing sounds from patient auscultations is vital.