Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Objective: To explore the relationship between inflammation, oxidative stress and poor myocardial perfusion in patients with acute ST-segment elevation myocardial infarction (STEMI) after primary percutaneous coronary intervention (PCI).
Background: Risk factors and mechanisms of poor reperfusion in patients with STEMI after primary PCI remain unclear.
Methods: A total of 143 patients who underwent primary PCI after STEMI were divided into good and poor perfusion groups according to sum-ST-segment resolution (sumSTR) and TIMI myocardial perfusion grade (TMP) results. Aortic sinus arterial blood was collected after primary PCI. The platelet-leukocyte aggregation (PLA), platelet-neutrophil aggregation (PNA), platelet-monocyte aggregation (PMA) and platelet-lymphocyte aggregation (PLyA) were measured by flow cytometry. The malondialdehyde (MDA) and superoxide dismutase (SOD) levels were measured by chemical colorimetry.
Results: The leukocyte count, neutrophil ratio and high-sensitivity C-reactive protein were significantly higher in the poor perfusion group than the good perfusion group (p < 0.05). Multiple linear regression analysis showed that neutrophil ratio was an independent risk factor of sumSTR in STEMI patients after primary PCI (p < 0.01). The poor myocardial perfusion group had higher levels of PLA, PNA, PMA and MDA (p < 0.05). There were no differences in PLyA and SOD levels between the good and poor myocardial perfusion groups (p > 0.05).
Conclusion: Inflammation and oxidative stress were related to poor myocardial perfusion in patients with STEMI after primary PCI.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.hrtlng.2016.06.005 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Multicompartment Darcy Flow Model With Patient-Specific Parameterization: Effect of Heterogeneity and Anisotropy in Porous Parameters.
Int J Numer Method Biomed Eng
September 2025
School of Mathematics and Statistics, University of Glasgow, Glasgow, UK.
Blood perfusion in cardiac tissues involves intricate interactions among vascular networks and tissue mechanics. Perfusion deficit is one of the leading causes of cardiac diseases, and modeling certain cardiac conditions that are clinically infeasible, invasive, or costly can provide valuable supplementary insights to aid clinicians. However, existing homogeneous perfusion models lack the complexity required for patient-specific simulations.
View Article and Find Full Text PDFEvaluation of the usefulness of the masking on un-smoothed image method in Tl myocardial perfusion SPECT.
Radiol Phys Technol
September 2025
Department of Cardiovascular Internal Medicine, NHO Kagoshima Medical Center, 8-1, Shiroyamacho, Kagoshima, Kagoshima, 892-0853, Japan.
In Tl myocardial perfusion single-photon emission computed tomography (SPECT), gastric wall uptake can impact the inferior wall. This study aimed to evaluate the effectiveness and usefulness of the masking on un-smoothed image (MUS) method for Tl myocardial perfusion SPECT. A hemispherical gastric wall phantom was created to simulate the gastric fundus located closest to the myocardium, and the activity was enclosed to achieve an SPECT count ratio against the myocardium equivalent to that observed in clinical practice.
View Article and Find Full Text PDFMyocardial Perfusion Imaging and Revascularization Predict Long-term All-cause Mortality in Patients with Suspected CAD.
Acad Radiol
September 2025
Department of Nuclear Medicine, National Taiwan University Hospital, Taipei, Taiwan (J.Y.H., C.L.K., K.L.C.); College of Medicine, National Taiwan University, Taipei, Taiwan (J.Y.H., C.K.H., K.L.C., Y.W.W.); Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan (C.K
Rationale And Objectives: The prognostic implications of myocardial perfusion imaging (MPI) are imperative to provide proper management of coronary artery disease (CAD). This study aimed to quantify the long-term prognostic value of MPI under routine clinical conditions.
Materials And Methods: This single-center retrospective cohort study evaluated all-cause mortality and cause-specific survival according to MPI findings in patients with suspected or known CAD who underwent diagnostic evaluation or assessment of myocardial ischemia and viability in a tertiary referral cardiovascular center.
Development of Diagnostic Reference Levels for Nuclear Medicine in Brazil: Insights from a University Hospital.
J Nucl Med Technol
September 2025
Anatomy and Imaging Department, Faculty of Medicine, Federal University of Minas Gerais, Belo Horizonte, Brazil; and.
Diagnostic reference levels (DRLs) are essential for optimizing radiologic practices and ensuring patient safety. This study aimed to establish typical DRLs for nuclear medicine (NM) procedures performed at a Brazilian public university hospital. A retrospective analysis of 2,609 patient records from 13 routine NM procedures was conducted.
View Article and Find Full Text PDFCardioplegic Machine Perfusion of Hearts Donated after Circulatory Death.
J Cardiovasc Transl Res
September 2025
Department of Cardiac Surgery, University Hospital Halle (Saale), University of Halle, Ernst-Grube-Straße 40, 06120, Halle (Saale), Germany.
We compared the effects of ex-vivo machine perfusion (EVMP) of hearts donated after circulatory death (DCD) with the single-shot solutions HTK-N and Del Nido cardioplegia (DNC) on left-ventricular (LV) contractility and myocardial microcirculation. In a DCD pig model, hearts were maintained by EVMP with hypothermic, oxygenated HTK-N (DCD-HTK-N; N = 8) or DNC (DCD-DNC; N = 8) followed by reperfusion with blood, including assessment of contractility and microcirculation with Laser-Doppler-Flow (LDF). We performed transcriptomics using microarrays.
View Article and Find Full Text PDF