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The purpose of this study was to test the hypothetical model of health-related quality of life (HRQOL) during the menopausal transition. The model was developed to test specific components of the Wilson and Cleary's model for HRQOL. A cross-sectional, correlational study was carried out using self-report questionnaires on a convenience sample of 162 Korean women in the menopausal transition. The model was tested by a path analysis using Analysis of Moment Structure (AMOS) program. The path analysis showed that 5 affecting variables explained 69% of the variance in HRQOL during the menopausal transition. Based on the results, the Wilson and Cleary's model may be useful in explaining HRQOL during the menopausal transition. Symptoms, functional status, and health perceptions mediated the effect of individual and environmental characteristics on HRQOL. However, the results suggest that some paths need to be added or modified in the model. To date, most research using Wilson and Cleary's model has been conducted in the United States, Africa, and Europe (e.g., Austria, Norway, and Spain). This study shows the applicability of the model in Asian people.
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http://dx.doi.org/10.1891/1541-6577.30.2.143 | DOI Listing |
Maturitas
August 2025
Chakri Naruebodindra Medical Institute, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Samut Prakan, Thailand. Electronic address:
Objectives: To assess the prevalence, associated factors, and quality-of-life impact of dry eye symptoms among perimenopausal and postmenopausal women in Thailand.
Study Design: This cross-sectional study, conducted from September to December 2024, included 262 women aged 41-60 years attending a gynaecology and menopause clinic at Ramathibodi Hospital. Participants completed the Ocular Surface Disease Index and the Menopause-Specific Quality of Life questionnaires.
J Obstet Gynaecol Res
September 2025
State Key Laboratory of Ultrasound in Medicine and Engineering, College of Biomedical Engineering, Chongqing Medical University, Chongqing, China.
Aim: To investigate the correlation between patient age and long-term re-intervention requirements for symptomatic uterine fibroids through stratified age-group analysis following ultrasound-guided high-intensity focused ultrasound (UsgHIFU) ablation therapy.
Methods: This retrospective cohort study evaluated 443 uterine fibroids from the Liuzhou Maternal and Child Healthcare Hospital (2018-2020). Post-ablation re-intervention trajectories were monitored over 36 months following UsgHIFU.
Clin Sci (Lond)
August 2025
Eurecat, Centre Tecnològic de Catalunya, Biotechnology Area, 43204 Reus, Spain.
Perimenopause is a transitional phase leading to female reproductive senescence, which can cause vasomotor symptoms and increase the risk of osteoporosis, obesity, and metabolic-related disturbances in middle-aged and older women. Nevertheless, little is known regarding the underlying mechanisms linked to menopausal transition, which could be of great value in designing new interventions addressed to improve the health of both perimenopausal and postmenopausal women. We used an ovarian-intact middle-aged model of rats resembling the characteristics of human perimenopause and applied liquid and gas chromatography quadrupole time-of-flight mass spectrometry approaches for the determination of polar and lipid-related metabolites to identify characteristic circulating signatures across perimenopause.
View Article and Find Full Text PDFWomens Health (Lond)
August 2025
Department of Epidemiology & Biostatistics, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada.
Background: The prevalence of poor sleep is increasing. Women and men have different sleep needs, and uniquely female life transitions, such as the perinatal period and menopause, are associated with further differences in sleep patterns. In Canada, sleep disparities across socioeconomic groups are profound, but sleep research rarely differentiates between women and men.
View Article and Find Full Text PDFEur J Obstet Gynecol Reprod Biol
August 2025
Fakher Mechatronic Research Center, Kerman University of Medical Sciences, Kerman, Iran; Research Management Centre, INTI International University, Putra Nilai, Malaysia. Electronic address:
Background: Hot flashes and night sweats (HFNS), the primary symptoms of the menopausal transition, can greatly affect women's quality of life. There is substantial evidence that cognitive-behavioral interventions positively influence the management of HFNS in women.
Objective: The aim of this study is to evaluate the effectiveness of a mobile-app-based cognitive-behavioral therapy (Meno-iCBT) on the problem rating of hot flashes and night sweats (HFNS).